BETA-ENDORPHIN IN THE BRAIN-STEM, PITUITARY, AND SPINAL-FLUID OF INFANTS AT AUTOPSY - RELATION TO SUDDEN INFANT DEATH SYNDROME
BETA-ENDORPHIN IN THE BRAIN-STEM, PITUITARY, AND SPINAL-FLUID OF INFANTS AT AUTOPSY - RELATION TO SUDDEN INFANT DEATH SYNDROME
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DOI：
10.1016/0379-0738(88)90010-2
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发表时间：
1988-07-01
影响因子：
2.2
通讯作者：
HOLLANDER, N
中科院分区：
文献类型：
--
作者：
HOLLANDER, N
免疫组织化学定位β-对40名婴儿的脑垂体和髓质进行了尸检，研究了脑内啡的含量。β-所有病例的垂体前叶细胞内均可见内啡肽免疫反应。在髓质中，β- 40例中有10例在楔束内侧核和外侧核的神经元中发现内啡肽免疫反应性。在这10个病例中，有8个婴儿死于婴儿猝死综合征（SIDS）以外的原因。25例SIDS病例中只有2例具有可证实的β-脑内啡在脑干核团中。β-所有病例的脊髓液中内啡肽水平与死因，年龄或性别无关。
Immunohistochemical localization of .beta.-endorphin was studied in the pituitaries and medullas of forty human infants at autopsy. .beta.-Endorphin immunoreactivity was found in anterior pituitary cells in all cases. In the medulla, .beta.-endorphin immunoreactivity was found in the neurons of the medial and lateral cuneate nuclei in ten out of the forty cases. In eight of these ten cases, the infants died of causes other than sudden infant death syndrome (SIDS). Only two of 25 SIDS cases had demonstrable .beta.-endorphin in the brainstem nuclei. .beta.-endorphin levels in the spinal fluids of all the cases showed no correlation to cause of death, age or gender.