Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy
Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy
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DOI：
10.2337/diabetes.51.3.819
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发表时间：
2002-03-01
期刊：
影响因子：
7.7
通讯作者：
Low, PA
中科院分区：
文献类型：
--
作者：
Kishi, M;Tanabe, J;Low, PA
慢性高血糖导致主要的感觉神经病变。最近的研究表明，背根神经节（DRG）神经元包括一个特定的目标，并可能是负责糖尿病感觉神经病变的重要并发症，因为高血糖超过6个月的结果，在vactiolar神经节病变相关的神经根病和远端感觉神经病变。我们对7只糖尿病大鼠和6只年龄和性别匹配的同窝仔进行了L5 DRG神经元的形态学分析。还进行了神经传导研究，并证实了神经病变。用链脲佐菌素诱发糖尿病;糖尿病持续时间为12个月。对照大鼠的DRG计数为15，304 +/- 991个神经元。7例糖尿病患者中有2例DRG计数减少，但组平均计数（14，847 +/-1，524）未显著减少。小神经元（B型）的数量大大超过大神经元（A型），比例为71：29。糖尿病组大细胞百分比明显低于对照组（P = 0.01）。大直径群体可以被细分为两组;通过这种细分，神经元的数量
Chronic hyperglycemia results in a predominantly sensory neuropathy. Recent studies suggest that dorsal root ganglion (DRG) neurons comprise a specific target and may be responsible for the important complication of diabetic sensory neuropathy, since hyperglycemia for longer than 6 months results in a vactiolar ganglionopathy with associated radiculopathy and distal sensory neuropathy. We undertook morphometric analysis of L5 DRG neurons in seven diabetic rats and six age- and sex-matched littermates. Nerve conduction studies were also performed, and neuropathy was confirmed. Diabetes was induced with streptozotocin; duration of diabetes was 12 months. The DRG count for control rats was 15,304 +/- 991 neurons. Two of seven diabetic DRG counts were reduced, but the group mean count at 14,847 +/- 1,524 was not significantly reduced. The number of small neurons (type B) considerably exceeded that of large neurons (type A), at a ratio of 71:29. The percentage of large cells was significantly reduced in diabetic compared with control rats (P = 0.01). The large-diameter population can be subdivided into two groups; with this subdivision, the number of neurons