Methicillin-Resistant Staphylococcus aureus (MRSA): Risk and Outcome of Colonized vs. Infected Patients
Methicillin-Resistant Staphylococcus aureus (MRSA): Risk and Outcome of Colonized vs. Infected Patients
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耐甲氧西林金黄色葡萄球菌 (MRSA)：定植患者与感染患者的风险和结果
DOI：
10.1017/s0195941700064791
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
E. Hutchinson
中科院分区：
文献类型：
--
作者：
J. Longfield;T. Townsend;D. Cruess;Maureen A. Stephens;Catherine Bishop;E. Bolyard;E. Hutchinson
摘要对204例耐甲氧西林金黄色葡萄球菌培养阳性患者进行回顾性研究，比较感染和定植患者。78名患者被定殖并且从未发生感染（C），24名患者被定殖并且随后感染（C III），并且102名患者在第一次培养时具有1次或多次MRSA医院感染（I）。最常见的感染部位是伤口（26.5%）和血流（20.7%），而呼吸道和手术伤口都是常见的定植部位。逐步判别分析发现，区分定植与感染可能性的最重要因素是近期既往住院、伤口清创史和侵入性手术次数。10%的（C）死亡，25.5%的（I）死亡。MRSA导致57.6%的（I）死亡（p<0.05）。这些结果强调了在MRSA流行的医院中区分（C）与（I）的重要性，以便可以开始早期特异性治疗。感染的危险因素应与获得生物体的危险因素区分开来。
Abstract A retrospective study of 204 patients culture positive for methicillin-resistant Staphylococcus aureus compared infected and colonized patients. Seventy-eight patients were colonized and never developed infection (C), 24 were colonized and subsequently infected (C➧I), and 102 patients had 1 or more nosocomial infections with MRSA at time of first culture (I). The most prevalent sites of infection were wound (26.5%) and bloodstream (20.7%), whereas the respiratory tract and surgical wounds were both frequent sites of colonization. Stepwise discriminant analysis found the most important factors in differentiating likelihood of colonization vs. infection were recent prior hospitalization, history of wound debridement, and number of invasive procedures. Ten percent of (C) died and 25.5% of (I) died. MRSA contributed to death in 57.6% of the (I) deaths (p<.05). These results underscore the importance of differentiating (C) vs. (I) in hospitals where MRSA is endemic so that early specific treatment may be initiated. Risk factors for infection should be discriminated from those for acquisition of the organism.
多重耐药金黄色葡萄球菌：医院感染的引入、传播和演变。
影响因子：
39.2
作者：
Locksley,RM;Cohen,ML;Quinn,TC;Tompkins,LS;Coyle,MB;Kirihara,JM;Counts,GW
通讯作者：
Counts,GW
耐甲氧西林金黄色葡萄球菌引起的医院感染的流行病学。
影响因子：
39.2
作者：
Thompson,RL;Cabezudo,I;Wenzel,RP
通讯作者：
Wenzel,RP