Association between trends in county-level opioid prescribing and reported rates of gonorrhea cases in the United States
Association between trends in county-level opioid prescribing and reported rates of gonorrhea cases in the United States
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DOI：
10.1016/j.annepidem.2019.06.007
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发表时间：
2019-08-01
影响因子：
5.6
通讯作者：
Kirkcaldy, Robert D.
中科院分区：
文献类型：
--
作者：
Abara, Winston E.;Hong, Jaeyoung;Kirkcaldy, Robert D.
目的：我们调查了阿片类药物处方率（阿片类药物滥用的代表）的县级趋势与美国男性淋病（GC）报告率之间的关联。方法：我们使用线性混合模型回归分析来评估2010- 2015年期间阿片类药物处方率的县级趋势与男性GC报告率之间的关联。结果：2010-2015年期间，县级阿片类药物处方率趋势与男性GC发生率呈正相关（β =-0.068，95%置信区间[Cl] =-0.030，-0.105）。然而，在阿片类药物处方率下降的县，这种关联的程度随着时间的推移而显著下降（β =-0.018，95% CI =-0.030，-0.006）并保持稳定（β =-0.020，95% CI =-0.038，-0.002），但在阿片类药物处方率增加的县保持不变（β =-0.029，95%CI =-0.058，-0.001）。结论：2010-2015年期间，我们发现县级阿片类药物处方率（阿片类药物滥用的代表）的增加与男性报告的GC率之间存在正相关，特别是在受阿片类药物危机影响最严重的县。将性健康与阿片类药物滥用干预措施相结合可能有助于解决美国的GC负担。爱思唯尔公司出版
Purpose: We investigated the association between county-level trends in opioid prescribing rates, a proxy for opioid misuse, and rates of reported gonorrhea (GC) among males in the United States.Methods: We used linear mixed-model regression analyses to evaluate the association between county level trends in opioid prescribing rates and rates of reported GC among males during 2010-2015.Results: There was a positive association between trends in county-level opioid prescribing rates and rates of GC among males (beta = -0.068, 95% confidence interval [Cl] = -0.030, -0.105) during 2010-2015. However, the magnitude of this association decreased significantly over time in counties where opioid prescribing rates decreased (beta = -0.018, 95% Cl = -0.030, -0.006) and remained stable (beta = -0.020, 95% Cl = -0.038, -0.002) but was unchanged in counties where opioid prescribing rates increased (beta = -0.029, 95% Cl = -0.058, -0.001).Conclusions: During 2010-2015, we found a positive association between increases in county-level opioid prescribing rates, a proxy for opioid misuse, and rates of reported GC among males especially in counties most affected by the opioid crisis. Integrating sexual health with opioid misuse interventions might be beneficial in addressing the GC burden in the United States. Published by Elsevier Inc.