Sequential peptide ligation by using a controlled cysteinyl prolyl ester (CPE) autoactivating unit
Sequential peptide ligation by using a controlled cysteinyl prolyl ester (CPE) autoactivating unit
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DOI：
10.1016/j.tetlet.2007.01.086
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发表时间：
2007-03-12
影响因子：
1.8
通讯作者：
Aimoto, Saburo
中科院分区：
文献类型：
--
作者：
Kawakami, Toru;Aimoto, Saburo
在天然化学连接条件下，将含有半胱氨酰脯氨酰酯（CPE）自活化单元的肽结构单元与半胱氨酰肽连接。CPE自活化功能可以通过巯基的保护来控制，允许肽结构单元在C或N末端的选择性连接。(c)2007爱思唯尔有限公司保留所有权利。
A peptide building block containing a cysteinyl prolyl ester (CPE) autoactivating unit was ligated with a cysteinyl peptide under native chemical ligation conditions. The CPE autoactivating function can be controlled by the protection of the thiol group, permitting the selective ligation of the peptide building block at either the C or N terminus. (c) 2007 Elsevier Ltd. All rights reserved.