Is there a direct role for erythrocytes in the immune response?
Is there a direct role for erythrocytes in the immune response?
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DOI：
10.1186/1297-9716-42-89
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发表时间：
2011-07-29
影响因子：
4.4
通讯作者：
MacKenzie SA
中科院分区：
文献类型：
--
作者：
Morera D;MacKenzie SA
在脊椎动物中，红细胞是高度丰富的循环细胞，除了哺乳动物外，红细胞在整个生命周期中都保持有核状态。与这些细胞相关的主要功能是呼吸气体交换，但其他功能，包括与免疫系统的相互作用，已被归因于这些细胞。许多病毒、原核生物和真核生物直接针对这种细胞类型，并在整个脊椎动物群体中报告了大量相关的病理。纵观主要文献，病毒和红细胞之间相互作用、入侵和复制的机制已被很好地描述，但对红细胞的功能反应研究较少。横跨脊椎动物的一系列零散的报告表明，这些细胞能够对病毒感染做出功能性反应。相比之下，在过去的十年里，利用人类红细胞进行的深入蛋白质组学研究取得了很大进展，提供了与蛋白质表达和潜在功能相关的丰富信息来源。此外，基因表达水平的信息正在变得可用。本文就红细胞与病原体的相互作用、红细胞在免疫中的作用作一综述，并结合最近的组学研究提出，有核红细胞可能在免疫反应中起直接作用。
Erythrocytes are highly abundant circulating cells in the vertebrates, which, with the notable exception of mammals, remain nucleated throughout the entire life cycle. The major function associated with these cells is respiratory gas exchange however other functions including interaction with the immune system have been attributed to these cells. Many viral, prokaryotic and eukaryotic pathogens directly target this cell type and across the vertebrate group a significant number of related pathologies have been reported. Across the primary literature mechanisms of interaction, invasion and replication between viruses and erythrocytes have been well described however the functional response of the erythrocyte has been poorly studied. A fragmented series of reports spanning the vertebrates suggests that these cells are capable of functional responses to viral infection. In contrast, in-depth proteomic studies using human erythrocytes have strongly progressed throughout the past decade providing a rich source of information related to protein expression and potential function. Furthermore information at the gene expression level is becoming available. Here we provide a review of erythrocyte-pathogen interactions, erythrocyte functions in immunity and propose in light of recent -omics research that the nucleated erythrocytes may have a direct role in the immune response.
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