Pellino enhances innate immunity in Drosophila
Pellino enhances innate immunity in Drosophila
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DOI：
10.1016/j.mod.2010.01.004
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发表时间：
2010-05-01
影响因子：
2.6
通讯作者：
Schoeck, Frieder
中科院分区：
文献类型：
--
作者：
Haghayeghi, Amirhossein;Sarac, Amila;Schoeck, Frieder
先天免疫反应是脊椎动物和无脊椎动物抵御感染性病原体的一种防御机制，部分是通过Toll通路介导的。接触细菌后，Toll受体被激活，刺激Pelle/IRAK激酶，最终导致转录因子NF-kappa B转位到细胞核。这里我们展示了Pellino，一种与激活的Pelle/IRAK相互作用的高度保守的蛋白质，在果蝇中发挥着天然免疫的正调节作用。(C)2010 Elsevier爱尔兰有限公司保留所有权利
The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappa B to the nucleus Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila (C) 2010 Elsevier Ireland Ltd All rights reserved