Effects of novelty on activity of lateral and medial prefrontal neurons
Effects of novelty on activity of lateral and medial prefrontal neurons
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DOI：
10.1016/j.neures.2006.10.017
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发表时间：
2007-02-01
影响因子：
2.9
通讯作者：
Tanaka, Keiji
中科院分区：
文献类型：
--
作者：
Matsumoto, Madoka;Matsumoto, Kenji;Tanaka, Keiji
新事件的检测对于适应不断变化的环境至关重要。前额叶皮层被认为是将注意力导向新事件的区域之一。在这里，我们研究了新奇的两个组成部分的影响：上下文新奇，这纯粹是当一个熟悉的事件发生在一个不可预测的情况或时间和功能新奇，这本身发生时，一个不熟悉的刺激出现在熟悉的人的期望。我们训练猴子完成一项任务，这项任务既包括新奇成分，又记录了前额叶皮层外侧和内侧区神经元的活动。当一个熟悉的视觉刺激出现在一个不可预测的背景下，大量的细胞在外侧和内侧分裂的反应增强。相比之下，增强反应的不熟悉的视觉刺激，主要是在细胞中观察到外侧前额叶皮层。这些结果表明，外侧和内侧司的前额叶皮层是差异参与控制的注意触发的新的感觉事件。(c)2006年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Detection of novel events is crucial for adapting to changing environments. The prefrontal cortex has been thought to be one of the areas involved in orienting attention to novel events. Here, we examined the effects of two components of novelty: context novelty, which purely happens when a familiar event occurs in an unpredicted situation or time and feature novelty, which happens by itself when an unfamiliar stimulus appears against the expectation of familiar ones. We trained monkeys on a task that included both novelty components and recorded the activity of neurons in the lateral and medial divisions of the prefrontal cortex. The responses of a substantial number of cells in both the lateral and medial divisions were enhanced when a familiar visual stimulus was presented in an unpredicted context. By contrast, enhancement of responses by the unfamiliarity of visual stimuli was observed mainly in cells in the lateral prefrontal cortex. These results suggest that the lateral and medial divisions of the prefrontal cortex are differentially involved in the control of attention triggered by novel sensory events. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.