Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings
Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings
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DOI：
10.1093/cercor/bhu315
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发表时间：
2016-03-01
期刊：
影响因子：
3.7
通讯作者：
Cavalleri, Gianpiero L.
中科院分区：
文献类型：
--
作者：
Alhusaini, Saud;Whelan, Christopher D.;Cavalleri, Gianpiero L.
颞叶皮质异常在海马硬化所致内侧颞叶癫痫（MTLE+HS）患者中很常见，并被认为与潜在机制相关。在本研究中，我们着手确定一组MTLE+HS患者及其无症状同胞颞叶皮质形态学改变的熟悉程度。应用基于表面的形态测量（SBM）方法处理从140名个体（50名单侧MTLE+HS患者，50名患者的无症状同胞和40名健康对照）获得的MRI数据。使用感兴趣区域的方法，颞叶皮层形态的改变，确定在患者和他们的无症状的同胞与对照组进行比较。MTLE+HS患者同侧前内侧区颞叶皮质形态改变，包括内嗅皮质、海马旁回和颞极。在无症状的同胞中也观察到轻微但相似的形态学变化模式，具有中等效应量。这些局部变化与大脑皮层表面积的共享收缩引起的体积损失有关。这些发现表明，颞叶皮层形态改变是常见的患者和他们的无症状的兄弟姐妹，并建议，这种本地化的特点可能是遗传的。
Temporal cortex abnormalities are common in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE+HS) and believed to be relevant to the underlying mechanisms. In the present study, we set out to determine the familiarity of temporal cortex morphologic alterations in a cohort of MTLE+HS patients and their asymptomatic siblings. A surface-based morphometry (SBM) method was applied to process MRI data acquired from 140 individuals (50 patients with unilateral MTLE+HS, 50 asymptomatic siblings of patients, and 40 healthy controls). Using a region-of-interest approach, alterations in temporal cortex morphology were determined in patients and their asymptomatic siblings by comparing with the controls. Alterations in temporal cortex morphology were identified in MTLE+HS patients ipsilaterally within the anterio-medial regions, including the entorhinal cortex, parahippocampal gyrus, and temporal pole. Subtle but similar pattern of morphology changes with a medium effect size were also noted in the asymptomatic siblings. These localized alterations were related to volume loss that appeared driven by shared contractions in cerebral cortex surface area. These findings indicate that temporal cortex morphologic alterations are common to patients and their asymptomatic siblings and suggest that such localized traits are possibly heritable.