Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: A potential perioperative marker
Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: A potential perioperative marker
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DOI：
10.1016/j.jtcvs.2005.10.052
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发表时间：
2006-03-01
影响因子：
6
通讯作者：
Fineman, JR
中科院分区：
文献类型：
--
作者：
Shih, CY;Sapru, A;Fineman, JR
目的：b型利钠肽是一种具有利尿、利钠和血管活性的心脏激素，用于成年心脏病患者的诊断、风险分层和管理。然而，尚未有研究确定b型利钠肽在先天性心脏病手术干预后的预后价值。本研究的目的是：(1)确定先天性心脏病体外循环修复后b型利钠肽水平的变化；(2)研究b型利钠肽水平与患者预后之间的潜在关联。方法：对51例接受先天性心脏病修补术的婴幼儿进行分析。测定手术前后b型利钠肽水平，评估术后12小时b型利钠肽水平对术后预后的预测能力。结果：体外循环分离后b型利钠肽水平升高，12小时峰值升高8倍(P
Objectives: B-type natriuretic peptide, a cardiac hormone with diuretic, natriuretic, and vasoactive properties, is used in the diagnosis, risk stratification, and management of adult cardiac patients. However, no study has yet determined the prognostic value of B-type natriuretic peptide after surgical intervention for congenital heart disease. The objectives of this study were (1) to determine alterations in B-type natriuretic peptide levels after repair of congenital heart disease with cardiopulmonary bypass and (2) to investigate potential associations between B-type natriuretic peptide levels and outcomes in this patient population.Methods: Fifty-one infants and children undergoing repair of congenital heart disease were studied. B-type natriuretic peptide levels were measured before and after surgical intervention, and the ability of the postoperative 12-hour B-type natriuretic peptide level to predict postoperative outcomes was evaluated.Results: B-type natriuretic peptide levels increased after separation from cardiopulmonary bypass, with an 8-fold peak increase at 12 hours (P