Hypermethylation ofDRD5Promoter Is a Biomarker Across 12 Cancer Types
Hypermethylation ofDRD5Promoter Is a Biomarker Across 12 Cancer Types
复制标题
DRD5 启动子的高甲基化是 12 种癌症类型的生物标志物
DOI：
10.1089/dna.2020.5829
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发表时间：
2020
影响因子：
3.1
通讯作者：
Hu Wangxiong
中科院分区：
文献类型：
--
作者：
Bai Rui;Mei Jinzhi;Hu Wangxiong
Aberrant DNA methylation is thought to be an early event in cancer development. Thus, identification of DNA methylation-based markers may provide valuable evidence in clinical decision-making. In this study, a DNA methylation dataset from 514 normal-tumor pairs is used to explore possible shared differentially methylated regions (DMRs) across 12 cancer types. Results showed that DMR in Dopamine receptor D5 (DRD5) promoter may be serviced as a good candidate biomarker across different cancer types. We further validated the extended DMR (292bp) inDRD5promoter using SEQUENOM MassARRAY platform. Detection ofDRD5promoter dynamic methylation will allow rapid risk assessment at diagnosis, for suspicious tumor with the tissue biopsies.
