High-performance liquid chromatography of cis-dichlorodiammineplatinum(II) using chemically-bonded and solvent-generated ion exchangers
High-performance liquid chromatography of cis-dichlorodiammineplatinum(II) using chemically-bonded and solvent-generated ion exchangers
复制标题
使用化学键合和溶剂生成的离子交换剂对顺式二氯二氨铂 (II) 进行高效液相色谱分析
DOI：
10.1016/s0021-9673(00)88094-2
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发表时间：
1981
影响因子：
4.1
通讯作者：
A. Repta
中科院分区：
文献类型：
--
作者：
C. Riley;L. Sternson;A. Repta
顺式-二氯二氨铂（II）（顺铂）是一种中性的正方形平面铂（II）配合物，可用于多种肿瘤的临床治疗，被发现保留在化学键合和溶剂产生的阴离子交换剂上。溶剂型阴离子交换剂是通过将十六烷基三甲基溴化铵吸附到疏水固定相表面而制备的。对离子强度、有机改性剂和温度的影响的调查揭示了两种体系之间的某些根本差异。然而，顺铂在这两种类型的阳离子固定相上的保留机制最容易解释的离子-偶极相互作用。
cis-Dichlorodiammineplatinum(II) (cisplatin), a neutral square planar platinum(II) complex useful in the clinical management of a variety of neoplasms, was found to be retained on chemically-bonded and solvent-generated anion exchangers. The solvent-generated anion exchanger was prepared by the adsorption of hexadecyltrimethylammonium bromide onto the surface of a hydrophobic stationary phase. Investigations into the effects of ionic strength, organic modifiers and temperature revealed certain fundamental differences between the two systems. However, the retention mechanism of cisplatin on both types of cationic stationary phases was most readily explained in terms of ion-dipole interaction.