Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma
Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma
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DOI：
10.1006/exmp.2001.2367
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发表时间：
2001-06-01
影响因子：
3.6
通讯作者：
Altieri, DC
中科院分区：
文献类型：
--
作者：
Lo Muzio, L;Staibano, S;Altieri, DC
细胞凋亡抑制剂（程序性细胞死亡）表达失调可能会通过异常延长细胞活力并促进治疗耐药性的增加而导致癌症。在本研究中，我们研究了凋亡抑制剂生存素在鳞状细胞癌（SCC）中的潜在表达和预后意义。通过免疫组织化学和蛋白质印迹分析了一系列 135 例 SCC 病例，其中 46 例口腔 SCC 和 89 例皮肤 SCC 中存活蛋白的表达。 Survivin 在 57 例（64%）皮肤鳞状细胞癌和 26 例（56%）口腔鳞状细胞癌中发现，加权 survivin 评分范围为 1 至 12。相比之下，正常口腔上皮、正常皮肤上皮和皮肤附件不表达 survivin。 Survivin 表达显着 (P < 0.05) 与大小 > 1.5 cm 的高级别和未分化肿瘤分离，并且总是与淋巴结转移相关。这些数据表明，生存素表达可以预测性地识别具有更具侵袭性和侵袭性临床表型的鳞状细胞癌病例，可能需要更密切的随访方案。 (C) 2001 年学术出版社。
Deregulated expression of inhibitors of apoptosis (programmed cell death) may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence of resistance to therapy. In this study, we investigated the potential expression and prognostic significance of the apoptosis inhibitor survivin in squamous cell carcinoma (SCC). A series of 135 cases of SCC including 46 oral SCC and 89 cutaneous SCC was analyzed for survivin expression by immunohistochemistry and Western blotting. Survivin was found in 57 cases (64%) of skin SCC and 26 cases (56%) of oral SCC, with weighted survivin scores ranging from 1 to 12. In contrast, normal oral epithelium, normal skin epithelium, and skin annexa did not express survivin. Survivin expression significantly (P < 0.05) segregated with high-grade and undifferentiated tumors with size >1.5 cm and invariably associated with lymph node metastasis. These data suggest that survivin expression may predictively identify cases of SCC with more aggressive and invasive clinical phenotype, potentially warranting closer follow-up protocols. (C) 2001 Academic Press.