Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients.
Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients.
复制标题
DOI：
10.1084/jem.158.1.74
复制
发表时间：
1983-07-01
期刊：
影响因子：
--
通讯作者：
Collins FM
中科院分区：
文献类型：
--
作者：
Orme IM;Collins FM
这项研究的结果表明，在对结核分枝杆菌静脉感染的初次免疫反应最严重时，取自小鼠的脾细胞具有将过继保护转移给结核分枝杆菌感染的受体的能力，但前提是这些受体首先通过胸腺切除术和伽马射线照射或亚致死照射使这些受体缺乏T细胞。需要类似的要求来证明暴露于急性气溶胶传播的结核分枝杆菌感染后对肺部的过继保护。在这两种感染模型中，成功的过继免疫疗法被证明是由 T 淋巴细胞介导的，这些 T 淋巴细胞是在供体动物体内针对免疫感染而获得的。建议本研究的结果可以作为后续分析 T 细胞介导的对结核分枝杆菌全身性和气源性感染的免疫应答性质的基本模型。
The results of this study demonstrate that spleen cells taken from mice at the height of the primary immune response to intravenous infection with Mycobacterium tuberculosis possess the capacity to transfer adoptive protection to M. tuberculosis-infected recipients, but only if these recipients are first rendered T cell-deficient, either by thymectomy and gamma irradiation, or by sublethal irradiation. A similar requirement was necessary to demonstrate the adoptive protection of the lungs after exposure to an acute aerosol-delivered M. tuberculosis infection. In both infectious models successful adoptive immunotherapy was shown to be mediated by T lymphocytes, which were acquired in the donor animals in response to the immunizing infection. It is proposed that the results of this study may serve as a basic model for the subsequent analysis of the nature of the T cell-mediated immune response to both systemic and aerogenic infections with M. tuberculosis.