Levels and toxicokinetic behaviors of PCDD, PCDF, and coplanar PCB congeners in common cormorants from Lake Biwa, Japan
Levels and toxicokinetic behaviors of PCDD, PCDF, and coplanar PCB congeners in common cormorants from Lake Biwa, Japan
复制标题
DOI：
10.1021/es0494858
复制
发表时间：
2004-07-15
影响因子：
11.4
通讯作者：
Tobata, S
中科院分区：
文献类型：
--
作者：
Kubota, A;Iwata, H;Tobata, S
多氯二苯并二恶英（PCDDs），多氯二苯并呋喃（PCDFs），共面多氯联苯（Co-PCBs）的浓度进行了测定，在肝脏和胸肌的普通鸬鹚（Phalacrocorax carbo），日本琵琶湖，收集。为了阐明这些化学品的毒代动力学行为和潜在毒性，本研究讨论了同系物在生命阶段和组织中的特定累积。总的2，3，7，8-四氯二苯并-对-二恶英毒性当量（TEQ）的范围为360至50 000皮克/克脂肪重量的肝脏和310至12 000皮克/克脂肪重量的胸肌。在已指定毒性当量系数的同系物中，多氯联苯126、2，3，4，7，8-P5 CDF和1，2，33，8-P5 CDD对肝脏中的总毒性当量贡献较大。随着鸬鹚的生长，肝脏中T-4-至H6 CON、P-5-和H（6）CDF以及Co-PCB（PCB 77除外）的浓度显著增加，导致与生命阶段相关的成分变化。肝脏与胸肌的浓度比显示，高氯化同系物优先在肝脏组织中积累。对于大多数同源物，浓度比率随着肝脏总毒性当量的增加而显著增加，表明其浓度依赖性肝隔离。这些结果表明存在肝结合蛋白，如细胞色素P450，可由这些化学物质诱导，其可能作为不同于芳烃受体的结合物质发挥作用。根据这些结果，我们得出结论，每种同系物的毒代动力学行为是生命阶段，组织和浓度依赖性。在风险评估中，应谨慎使用暴露于不同浓度的多种同系物的野生动物种群中的十氯苯酚，即使是在一个物种内。
Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs) were determined in the liver and pectoral muscle of common cormorants (Phalacrocorax carbo) collected from Lake Biwa, Japan. To clarify the toxicokinetic behaviors and potential toxicities of these chemicals, the present study addresses life-stage- and tissue-specific accumulation of the congeners. Total 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (TEQs) were in the range of 360 to 50 000 pg/g lipid weight in the liver and 310 to 12 000 pg/g lipid weight in the pectoral muscle. Among congeners, for which toxic equivalency factors were assigned, PCB126, 2,3,4,7,8-P5CDF, and 1,2,33,8-P5CDD made a greater contribution to total TEQs in the liver. Hepatic concentrations of T-4- to H6CON, P-5- and H(6)CDFs, and Co-PCBs (except PCB77) significantly increased with growth of cormorants, leading to life-stage-related compositional changes. The concentration ratios of liver to pectoral muscle revealed preferential accumulation of higher chlorinated congeners in hepatic tissue. For most congeners, concentration ratios significantly increased with an increase in hepatic total TEQs, suggesting their con centration-dependent hepatic sequestration. These results imply the presence of hepatic binding protein(s) such as cytochrome P450, inducible by these chemicals, which may function as a binding species different from aryl hydrocarbon receptor. On the basis of these results, we conclude that the toxicokinetic behavior of each congener is life-stage-, tissue-, and concentration-dependent. TEN in wildlife populations exposed to multiple congeners with varying concentrations should be used with caution for risk assessment, even within a species.