Serotonin and the Neural Processing of Facial Emotions in Adults With Autism An fMRI Study Using Acute Tryptophan Depletion
Serotonin and the Neural Processing of Facial Emotions in Adults With Autism An fMRI Study Using Acute Tryptophan Depletion
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DOI：
10.1001/archgenpsychiatry.2012.513
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发表时间：
2012-10-01
影响因子：
--
通讯作者：
Murphy, Declan G. M.
中科院分区：
文献类型：
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作者：
Daly, Eileen M.;Deeley, Quinton;Murphy, Declan G. M.
背景：患有自闭症谱系障碍 (ASD) 的人在社会行为方面存在终生缺陷，并且对面部情绪表达的行为和神经反应存在差异。其生物学基础尚不完全清楚，但它可能包括神经递质（例如血清素）的作用差异，这些神经递质在健康中调节面部情绪处理。虽然一些自闭症谱系障碍患者的血清素系统存在显着差异，但据我们所知，没有人使用急性色氨酸消耗（ATD）和功能磁共振成像研究其在自闭症谱系障碍成人和对照受试者的面部情绪处理过程中的作用。目的：比较 ATD 对自闭症谱系障碍男性和健康对照受试者的大脑对主要面部情绪表达的反应的影响。设计：双盲、安慰剂对照、交叉试验 ATD 和功能磁共振成像，以测量厌恶、恐惧、快乐和悲伤面部表情的偶然处理。地点：伦敦国王学院精神病学研究所、英国南伦敦和莫兹利国家健康服务基金会信托基金。参与者：14 名智力正常的自闭症男性和 14 名在性别、年龄或整体智力上没有显着差异的对照组受试者。主要结果指标：对情绪面部表情的血氧水平依赖性反应。结果：大脑激活受到以下因素的差异调节： ATD 取决于社交大脑网络区域内的诊断群体和情绪类型。例如，厌恶面孔的处理与额内侧回和舌回的相互作用相关，而快乐面孔的处理与额中回和壳核的相互作用相关。结论：与对照组相比，自闭症谱系障碍患者对情绪面部表情的调节与血清素的调节存在显着差异。这些差异因情绪类型而异，并发生在社会大脑区域，这些区域已被证明与血清素合成/受体或转运蛋白密度的群体差异有关。Arch Gen Psychiatry。 2012年； 69（10）：1003-1013。 2012 年 6 月 4 日在线发布。doi: 10.1001/archgenpsychiatry.2012.513
Context: People with autism spectrum disorders (ASDs) have lifelong deficits in social behavior and differences in behavioral as well as neural responses to facial expressions of emotion. The biological basis to this is incompletely understood, but it may include differences in the role of neurotransmitters such as serotonin, which modulate facial emotion processing in health. While some individuals with ASD have significant differences in the serotonin system, to our knowledge, no one has investigated its role during facial emotion processing in adults with ASD and control subjects using acute tryptophan depletion (ATD) and functional magnetic resonance imaging.Objective: To compare the effects of ATD on brain responses to primary facial expressions of emotion in men with ASD and healthy control subjects.Design: Double-blind, placebo-controlled, crossover trial of ATD and functional magnetic resonance imaging to measure brain activity during incidental processing of disgust, fearful, happy, and sad facial expressions.Setting: Institute of Psychiatry, King's College London, and South London and Maudsley National Health Service Foundation Trust, England.Participants: Fourteen men of normal intelligence with autism and 14 control subjects who did not significantly differ in sex, age, or overall intelligence.Main Outcome Measures: Blood oxygenation level-dependent response to facial expressions of emotion.Results: Brain activation was differentially modulated by ATD depending on diagnostic group and emotion type within regions of the social brain network. For example, processing of disgust faces was associated with interactions in medial frontal and lingual gyri, whereas processing of happy faces was associated with interactions in middle frontal gyrus and putamen.Conclusions: Modulation of the processing of facial expressions of emotion by serotonin significantly differs in people with ASD compared with control subjects. The differences vary with emotion type and occur in social brain regions that have been shown to be associated with group differences in serotonin synthesis/receptor or transporter density.Arch Gen Psychiatry. 2012; 69(10): 1003-1013. Published online June 4, 2012. doi: 10.1001/archgenpsychiatry.2012.513