Habitual sleep is associated with both source memory and hippocampal subfield volume during early childhood
Habitual sleep is associated with both source memory and hippocampal subfield volume during early childhood
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DOI：
10.1038/s41598-020-72231-z
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发表时间：
2020-09-17
影响因子：
4.6
通讯作者：
Spencer, Rebecca M. C.
中科院分区：
文献类型：
--
作者：
Riggins, Tracy;Spencer, Rebecca M. C.
先前的研究已经确定了儿童早期睡眠和记忆的重要发育变化。这些变化分别与大脑发育有关，但很少有研究探索它们在这一发育时期的相互关系。本报告的目的是在200名（100名女性）典型发育中的4至8岁儿童中探讨这些关联。我们研究了习惯性睡眠模式（24小时睡眠时间，午睡状态）是否与儿童在源记忆任务中的表现和海马体子区体积有关。结果显示，在所有参与者中，在控制年龄后，习惯性睡眠时间与源记忆表现呈正相关。此外，在年龄较小（4-6岁，n=67）而年龄较大（6-8岁，n=70）的儿童中，习惯性睡眠时间与海马头亚区容积（CA2-4/DG）相关。此外，在年幼的儿童中，海马子区的体积随午睡状态的变化而变化；仍在午睡的儿童（n=28）体内的CA1体积比已经过渡到午睡状态的儿童（n=39）大。总之，这些发现与假设一致，即习惯性午睡的儿童可能有更多不成熟的认知网络，如海马完整性所示。此外，这些结果进一步阐明了为什么睡眠在儿童早期很重要，因为这是大脑发育的重要时期。
Previous research has established important developmental changes in sleep and memory during early childhood. These changes have been linked separately to brain development, yet few studies have explored their interrelations during this developmental period. The goal of this report was to explore these associations in 200 (100 female) typically developing 4- to 8-year-old children. We examined whether habitual sleep patterns (24-h sleep duration, nap status) were related to children's performance on a source memory task and hippocampal subfield volumes. Results revealed that, across all participants, after controlling for age, habitual sleep duration was positively related to source memory performance. In addition, in younger (4-6 years, n=67), but not older (6-8 years, n=70) children, habitual sleep duration was related to hippocampal head subfield volume (CA2-4/DG). Moreover, within younger children, volume of hippocampal subfields varied as a function of nap status; children who were still napping (n=28) had larger CA1 volumes in the body compared to children who had transitioned out of napping (n=39). Together, these findings are consistent with the hypothesis that habitually napping children may have more immature cognitive networks, as indexed by hippocampal integrity. Furthermore, these results shed additional light on why sleep is important during early childhood, a period of substantial brain development.