Alcohol Consumption and Mortality in Patients With Cardiovascular Disease A Meta-Analysis
Alcohol Consumption and Mortality in Patients With Cardiovascular Disease A Meta-Analysis
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DOI：
10.1016/j.jacc.2010.01.006
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发表时间：
2010-03-30
影响因子：
24
通讯作者：
de Gaetano, Giovanni
中科院分区：
文献类型：
--
作者：
Costanzo, Simona;Di Castelnuovo, Augusto;de Gaetano, Giovanni
目的本研究旨在量化有心血管事件史的患者饮酒与心血管疾病及总死亡率的关系。目前还没有关于饮酒与心血管疾病患者继发事件的可能关联的广泛的荟萃分析。方法通过PubMed和EMBASE检索2009年10月的文章。确定了54篇文章，但只有8篇被选为我们的分析对象，其中包括16,351名有心血管疾病病史的患者。次要事件为心血管或全因死亡。所有入选研究均为前瞻性研究。采用加权最小二乘二阶分数次多项式回归模型对数据进行汇总分析。结果心血管病死亡率的Meta分析呈J型汇总曲线，每天饮酒26g左右的酒精具有显著的最大保护作用(平均22%)。在任何死因死亡率的Meta分析中，根据患者类型或研究的特点，在总体分析(平均最大保护率为18%，5~10g/d)和所有分组中观察到J形混合曲线。结论在心血管疾病患者中，轻度至中度饮酒(5~25g/d)与心血管和全因死亡率的降低显著相关。(J Am Coll心脏ol 2010；55：1339-47)(C)2010，美国心脏病学会基金会
Objectives The purpose of this study was to quantify the relation between alcohol consumption and cardiovascular and total mortality in patients with a history of cardiovascular events.Background Regular, moderate alcohol consumption by healthy people is associated with lower cardiovascular and all-cause mortality. No extensive meta-analysis is presently available on the possible association of alcohol consumption with secondary events in patients with cardiovascular disease.Methods Articles were retrieved through October 2009 by search in PubMed and EMBASE. Fifty-four publications were identified, but only 8 were selected for our analyses, including 16,351 patients with a history of cardiovascular disease. Secondary events were cardiovascular or all-cause mortality. All selected studies were prospective. Data were pooled with a weighted, least-squares regression analysis of second-order fractional polynomial models.Results The meta-analysis on cardiovascular mortality showed a J-shaped pooled curve with a significant maximal protection (average 22%) by alcohol at approximately 26 g/day. In the meta-analysis on mortality for any cause, J-shaped pooled curves were observed in the overall analysis (average maximal protection of 18% in the range of 5 to 10 g/day) and in all subgroups according to either the type of patients or the characteristics of the studies.Conclusions In patients with cardiovascular disease, light to moderate alcohol consumption (5 to 25 g/day) was significantly associated with a lower incidence of cardiovascular and all-cause mortality. (J Am Coll Cardiol 2010; 55: 1339-47) (C) 2010 by the American College of Cardiology Foundation