CONVERTING A EUKARYOTIC TRANSCRIPTIONAL INHIBITOR INTO AN ACTIVATOR
CONVERTING A EUKARYOTIC TRANSCRIPTIONAL INHIBITOR INTO AN ACTIVATOR
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DOI：
10.1016/0092-8674(88)90030-x
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发表时间：
1988-11-04
期刊：
影响因子：
64.5
通讯作者：
PTASHNE, M
中科院分区：
文献类型：
--
作者：
MA, J;PTASHNE, M
GAL80是酵母转录激活剂GAL4的抑制剂，通过在其中插入酸性激活序列而转化为激活剂。这种混合激活剂不直接与DNA结合，但通过与GAL4的衍生物相互作用而进入DNA，GAL4的衍生物与DNA和GAL80相互作用。
GAL80, an inhibitor of the yeast transcriptional activator GAL4, is converted into an activator by inserting an acidic activating sequence into it. This hybrid activator does not bind to DNA directly, but is brought to DNA by interacting with a derivative of GAL4 that interacts with both DNA and GAL80.