Red blood cell age and potentiation of transfusion-related pathology in trauma patients
Red blood cell age and potentiation of transfusion-related pathology in trauma patients
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DOI：
10.1111/j.1537-2995.2011.03098.x
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发表时间：
2011-04-01
期刊：
影响因子：
2.9
通讯作者：
Patel, Rakesh P.
中科院分区：
文献类型：
--
作者：
Weinberg, Jordan A.;Barnum, Scott R.;Patel, Rakesh P.
与输注储存的红细胞（RBC）相关的特定阴性临床表现以及导致此类现象的相应机制仍不清楚。我们最近的研究表明，白细胞减少的老年红细胞单位增强了创伤患者的输血相关毒性。我们的假设是，输注相对较老的血液会阻碍微血管灌注。提出的介导这种微循环改变的中心机制包括：1）RBC依赖性控制的一氧化氮介导的血管舒张稳态的丧失和2）免疫细胞和补体激活。在这篇综述中，我们概述了我们的假设的背景，并详细介绍了我们目前的调查对这种病理生理的理解。
The specific negative clinical manifestations associated with the transfusion of stored red blood cells (RBCs) and the corresponding mechanisms responsible for such phenomena remain poorly defined. Our recent studies document that leukoreduced older RBC units potentiate transfusion-related toxicity in trauma patients. It is our hypothesis that the transfusion of relatively older blood impedes microvascular perfusion. The central mechanisms proposed to mediate this microcirculatory alteration include: 1) the loss of RBC-dependent control of nitric oxide-mediated homeostasis concerning vasodilation and 2) immune cell and complement activation. In this review, we outline the background for our hypothesis and detail our current investigations toward the understanding of this pathophysiology.