CRYPTOCOCCAL INFECTION FOLLOWING STEROID THERAPY
CRYPTOCOCCAL INFECTION FOLLOWING STEROID THERAPY
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DOI：
10.7326/0003-4819-56-1-114
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发表时间：
1962-01-01
影响因子：
39.2
通讯作者：
RAMBO, ON
中科院分区：
文献类型：
--
作者：
GOLDSTEIN, E;RAMBO, ON
一例隐球菌感染在49岁的妇女谁接受类固醇治疗类风湿关节炎9年报告。该病例的特征提示对真菌病有类固醇增强的易感性。对1950年至1960年的英文文献进行了回顾，以确定类固醇治疗是否会增加隐球菌感染的易感性。在报告的隐球菌病病例中，147例有足够的临床资料供分析。其中8例（5.4%）发生在类固醇治疗期间或之后。在这8例病例中，有3例有强有力的临床证据表明类固醇的使用增加了患者对隐球菌感染的易感性。所分析的隐球菌病病例中，9.5%发生在网状内皮恶性肿瘤患者中。这是唯一一个感染发生率超过类固醇治疗组的广泛类别。从这些数据推断，类固醇治疗确实增加对隐球菌感染的易感性。
A case of cryptococcal infection in a 49-year-old woman who for 9 years had received steroid therapy for rheumatoid arthritis is reported. Features of the case suggested a steroid-enhanced susceptibility to mycosis. A review of the literature in English from 1950 to 1960 was undertaken to determine whether steroid therapy increases susceptibility to cryptococcal infection. Of the reported cases of cryp-tococcosis, 147 had sufficient clinical data for analysis. Of these, 8 (5.4%) occurred during or immediately after steroid therapy. In 3 of these 8 cases there was strong clinical evidence that administration of steroids enhanced the patients'' susceptibility to cryptococcal infection. Of the cases of cryptococcosis analyzed, 9.5% occurred in patients with reticuloendothelial malignancy. This broad category was the only one with an incidence of infection that exceeded that of the steroid therapy group. From these data it is inferred that steroid therapy does enhance susceptibility to cryptococcal infection.