Quantitative and Semiquantitative Measures of Regional Pulmonary Microvascular Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity The Multiethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
Quantitative and Semiquantitative Measures of Regional Pulmonary Microvascular Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity The Multiethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
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DOI：
10.1097/rli.0b013e318281057d
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发表时间：
2013-04-01
影响因子：
6.7
通讯作者：
Vogel-Claussen, Jens
中科院分区：
文献类型：
--
作者：
Hueper, Katja;Parikh, Megha A.;Vogel-Claussen, Jens
目的：本研究的目的是评估慢性阻塞性肺病（COPD）患者局部肺实质灌注的定量和半定量测量与整体肺灌注（GLP）和肺弥散量（DLCO）的关系。材料和方法：在动脉粥样硬化性COPD研究的多种族研究中，共对143名参与者进行了动态对比检查，增强肺灌注磁共振成像（MRI）在1.5 T。肺微血管血流量（PBF）的计算是在一个像素的基础上，通过使用双团技术和费米函数模型。根据肺实质的信号强度-时间曲线计算局部肺微血管灌注的半定量参数。观察者内和观察者间的变异系数（CV）和定量和半定量MRI参数之间的相关性，并与GLP和DLCO determined.Results：肺微血管灌注的定量和半定量参数是可重复的，与CV的所有参数小于10%。此外，这些MRI参数与GLP和DLCO相关，PBF与GLP之间具有良好的一致性。定量和半定量MRI参数密切相关（例如，最大信号增加与PBF的r = 0.86）。在没有COPD的参与者中，肺灌注的生理分布可以通过区域MRI测量来确定。结论：区域肺微血管灌注可以可靠地从动态增强MRI量化。磁共振成像衍生的定量和半定量灌注测量与GLP和DLCO相关。
Objectives: The aim of this study was to evaluate the quantitative and semi-quantitative measures of regional pulmonary parenchymal perfusion in patients with chronic obstructive pulmonary disease (COPD) in relationship to global lung perfusion (GLP) and lung diffusing capacity (DLCO).Materials and Methods: A total of 143 participants in the Multiethnic Study of Atherosclerosis COPD Study were examined by dynamic contrast-enhanced pulmonary perfusion magnetic resonance imaging (MRI) at 1.5 T. Pulmonary microvascular blood flow (PBF) was calculated on a pixel-by-pixel basis by using a dual-bolus technique and the Fermi function model. Semiquantitative parameters for regional pulmonary microvascular perfusion were calculated from signal intensity-time curves in the lung parenchyma. Intraoberserver and interobserver coefficients of variation (CVs) and correlations between quantitative and semiquantitative MRI parameters and with GLP and DLCO were determined.Results: Quantitative and semiquantitative parameters of pulmonary microvascular perfusion were reproducible, with CVs for all parameters of less than 10%. Furthermore, these MRI parameters were correlated with GLP and DLCO, and there was good agreement between PBF and GLP. Quantitative and semiquantitative MRI parameters were closely correlated (eg, r = 0.86 for maximum signal increase with PBF). In participants without COPD, the physiological distribution of pulmonary perfusion could be determined by regional MRI measurements.Conclusion: Regional pulmonary microvascular perfusion can reliably be quantified from dynamic contrast-enhanced MRI. Magnetic resonance imaging-derived quantitative and semiquantitative perfusion measures correlate with GLP and DLCO.