Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course.
Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course.
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偏头痛是多发性硬化症的并发症，与症状较重的多发性硬化症病程相关。
DOI：
10.1007/s10194-010-0237-9
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发表时间：
2010-10
影响因子：
7.4
通讯作者：
Lipton, R. B.
中科院分区：
文献类型：
--
作者：
Kister, Ilya;Caminero, A. B.;Monteith, T. S.;Soliman, A.;Bacon, T. E.;Bacon, J. H.;Kalina, J. T.;Inglese, M.;Herbert, J.;Lipton, R. B.
关键词：
本研究的目的是：（1）使用经验证的自填诊断问卷评估多发性硬化（MS）患者偏头痛的相对频率，并比较MS门诊患者与年龄和性别匹配的历史人群对照的偏头痛发生率;（2）比较MS伴偏头痛患者和无头痛MS患者的临床和影像学特征。我们进行了一项横断面研究，使用基于美国偏头痛患病率和预防（AMPP）研究的问卷来评估前往MS诊所就诊的MS患者的人口统计学特征、头痛特征和临床特征。我们比较了MS门诊患者和AMPP队列中偏头痛的相对频率。我们还比较了MS伴偏头痛患者与无头痛的MS对照组的临床和影像学特征。在204例MS患者中，女性[55.7 vs. 17.1%;患病率（PR）= 3.26，p < 0.001]和男性[18.4 vs. 5.6%; PR = 3.29，p < 0.001]偏头痛的相对频率是对照人群的三倍。在控制年龄、性别、病程、β-干扰素使用和抑郁的一系列逻辑回归模型中，MS患者的偏头痛与三叉神经和枕神经痛、面部疼痛、Lhermitte征、颞下颌关节疼痛、非头痛性疼痛和既往抑郁史显著相关（p < 0.01）。偏头痛状态与患者衍生残疾分级量表或脑MRI T2病变负荷的残疾无显著相关性。偏头痛在MS诊所患者中的发生率是一般人群的三倍。MS-偏头痛组比MS-无头痛组更有症状。
The objectives of this study were: (1) to assess relative frequency of migraine in multiple sclerosis (MS) patients using the validated self-administered diagnostic questionnaire, and to compare the migraine rates in MS outpatients to age- and gender-matched historical population controls; (2) to compare clinical and radiographic characteristics in MS patients with migraine and headache-free MS patients. We conducted a cross-sectional study to assess the demographic profiles, headache features and clinical characteristics of MS patients attending a MS clinic using a questionnaire based on the American Migraine Prevalence and Prevention (AMPP) study. We compared the relative frequency of migraine in MS clinic patients and AMPP cohort. We also compared clinical and radiographic features in MS patients with migraine to an MS control group without headache. Among 204 MS patients, the relative frequency of migraine was threefold higher than in population controls both for women [55.7 vs. 17.1%; prevalence ratio (PR) = 3.26, p < 0.001] and men (18.4 vs. 5.6%; PR = 3.29, p < 0.001). In a series of logistic regression models that controlled for age, gender, disease duration, β-interferon use, and depression, migraine in MS patients was significantly associated (p < 0.01) with trigeminal and occipital neuralgia, facial pain, Lhermitte’s sign, temporomandibular joint pain, non-headache pain and a past history of depression. Migraine status was not significantly associated with disability on patient-derived disability steps scale or T2 lesion burden on brain MRI. Migraine is three-times more common in MS clinic patients than in general population. MS–migraine group was more symptomatic than the MS–no headache group.
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影响因子：
56.9
作者：
TEITELBAUM, P;CYTAWA, J
通讯作者：
CYTAWA, J
影响因子：
9.9
作者：
Marrie, R. A.;Horwitz, R.;Vollmer, T.
通讯作者：
Vollmer, T.
影响因子：
9.9
作者：
Lipton, R. B.;Bigal, M. E.;Stewart, W. F.
通讯作者：
Stewart, W. F.
影响因子：
9.9
作者：
Stewart, WF;Lipton, RB;Sawyer, J
通讯作者：
Sawyer, J
影响因子：
5
作者：
Diamond, Seymour;Bigal, Marcelo E.;Lipton, Richard B.
通讯作者：
Lipton, Richard B.