Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004-2013
Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004-2013
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DOI：
10.1111/coa.13124
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发表时间：
2018-10-01
影响因子：
2.1
通讯作者：
Yang, S.
中科院分区：
文献类型：
--
作者：
Huang, S. -J.;Tang, Y. -Y.;Yang, S.
目的 确定诊断时年龄和其他因素对鼻咽癌 (NPC) 生存的影响。设计、背景和参与者选择了 3103 名患者的回顾性、基于人群的队列研究，其记录在 2004 年至 2013 年间提交给监测、流行病学和最终结果 (SEER) 数据库。我们评估了 20 岁或以上诊断为原发性、非转移性癌症的患者的人口学和临床特征NPC。主要结局指标总生存率 (OS) 以及 OS 风险和 NPC 特异性生存率。结果 1 年、3 年和 5 年总生存率分别为 85.8%、71.0% 和 62.6%。年龄较大是 OS 较差的一个重要预测因素，华人也是如此。我们还确定，中年白人患者的死亡风险高于同一种族/族裔的年轻患者，但中年黑人或华裔患者则不然。当比较患有 N0-1 期疾病和 N2-3 期疾病的老年患者的生存率时，淋巴结 (N) 0-1 期疾病是 OS 较差的重要预测因子。最后，我们发现与单身患者相比，已婚患者的死亡风险较低。结论老年鼻咽癌患者的生存率低于年轻患者。种族/民族、婚姻状况和疾病阶段是重要的风险调节因素。总的来说，我们的结果表明老年患者的管理需要优化。
ObjectivesTo determine the impact of age at diagnosis and other factors on survival in nasopharyngeal carcinoma (NPC).Design, Setting and ParticipantsA retrospective, population-based cohort study of 3103 patients are selected, whose records were submitted to the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. We evaluated the demographic and clinical characteristics of patients who were 20years or older with a diagnosis of primary, non-metastatic NPC.Main outcome measuresOverall survival (OS) and risks of OS and NPC-specific survival.ResultsOverall survival rates at 1, 3, and 5years were 85.8%, 71.0%, and 62.6%, respectively. Older age was a significant predictor of poor OS, as was Chinese ethnicity. We also determined that middle-aged white patients, but not middle-aged black or Chinese patients, were at a higher risk of death than were younger patients of the same race/ethnicity. Nodal (N) stage 0-1 disease was a significant predictor of poor OS when comparing survival of older patients with N0-1 vs N2-3 stage disease. Finally, we found that married patients had a decreased risk of death when compared to those who were single.ConclusionsThe survival of older patients with NPC is inferior to that of younger patients. Race/ethnicity, marital status, and stage of disease are important modifiers of risk. Collectively, our results indicate that management of older patients requires optimisation.