Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma
Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma
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DOI：
10.1016/j.rmed.2008.08.010
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发表时间：
2009-02-01
影响因子：
4.3
通讯作者：
Weiss, Scott T.
中科院分区：
文献类型：
--
作者：
Haselkorn, Tmirah;Fish, James E.;Weiss, Scott T.
目的：在参加《哮喘流行病学和自然史：结果和治疗方案》(Tenor)研究的成人重症或难治性哮喘患者中，评估体重变化对哮喘控制、哮喘相关生活质量、激素发作次数和哮喘症状恶化的影响。方法：根据基线体重和12个月随访体重的a+/-5磅(2.27公斤)差，我们将2396名Tenor患者分为三组(体重下降5磅，稳定，体重增加5磅)。我们使用比例优势和Logistic回归模型来评估体重变化对哮喘治疗评估问卷(ATAQ)和哮喘生活质量问卷(AQLQ)评分、病情恶化和激素发作的影响。结果：在基线和随访的12个月期间，体重增加=5[b(2.27 kg)]的哮喘患者报告哮喘控制较差(调整后的优势比[OR]：1.22；95%可信区间[CI]：1.01-1.49；生活质量较差(最小二乘均值：-0.18；95%CI：-0.30~-0.06；p=0.003)，激素暴发次数(OR：1.31；CI：1.04~1.66；p=0.02)高于维持基线体重或减重5磅(2.27 kg)的患者。预防体重增加的策略可以帮助患者实现更好的哮喘控制，并提高与哮喘相关的生活质量。(C)2008爱思唯尔有限公司。保留所有权利。
Objective: To evaluate the effects of weight change on asthma control, asthma-related quality of life, number of steroid bursts, and exacerbation of asthma symptoms in a population of adult patients with severe or difficult-to-treat asthma who participated in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.Methods: We categorized 2396 TENOR patients >18 years into three groups (>= 5 lb loss, stable, >= 5 lb gain), based on a +/- 5 lb (2.27 kg) difference between baseline and 12-month follow-up weight. We used proportional odds and Logistic regression models to evaluate the effect of weight change on Asthma Therapy Assessment Questionnaire (ATAQ) and Asthma Quality of Life Questionnaire (AQLQ) scores, exacerbations, and steroid bursts at the 12-month follow-up.Results: Asthma patients who gained >= 5 [b (2.27 kg) during the 12-month interval between baseline and follow-up reported poorer asthma control (adjusted odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.01-1.49; p = 0.04), worse quality of life (Least square means: -0.18; 95% CI: -0.30 to -0.06; p = 0.003), and a greater number of steroid bursts (OR: 1.31; CI: 1.04-1.66; p = 0.02) than patients who maintained their baseline weight or lost >= 5 lb (2.27 kg).Conclusion: Increased weight is associated with worse asthma-related health outcomes. Strategies to prevent weight gain could help patients achieve better asthma control and improve asthma-related quality of life. (C) 2008 Elsevier Ltd. All rights reserved.