Roles of ion transport in control of cell motility.
Roles of ion transport in control of cell motility.
复制标题
离子转运在细胞运动控制中的作用
DOI：
10.1002/cphy.c110056
复制
发表时间：
2013
影响因子：
5.8
通讯作者：
Albrecht Schwab
中科院分区：
文献类型：
--
作者：
Christian Stock;Florian T. Ludwig;Peter J. Hanley;Albrecht Schwab
细胞运动是生命的基本特征。它对生殖、繁殖、胚胎发育和愈合过程（如伤口闭合和成功的免疫防御）至关重要。如果失控，细胞运动可能会危及生命，例如在转移或自身免疫性疾病中。无论是纤毛/鞭毛或变形虫运动，受控的运动总是需要一个协调的行动的离子通道和转运，细胞骨架元素，和信号级联。跨质膜的离子转运通过影响膜电位和电压敏感性离子通道、通过在水通道蛋白的帮助下诱导局部体积变化以及通过调节胞质Ca 2+和H+浓度来促进细胞运动。电压敏感性离子通道在电场中充当电压检测器，从而实现趋电性;局部肿胀促进前缘突起的生长，而局部收缩伴随着细胞后部的收缩;细胞溶质Ca 2+浓度通过马达蛋白（如肌球蛋白或动力蛋白）对细胞骨架动力学产生主要影响;细胞内和细胞外H+浓度通过调节胞质溶胶中酶和信号分子的活性以及细胞表面粘附分子的活化状态来调节细胞迁移和粘附。除了离子转运的实际过程之外，通道和转运蛋白都通过成为粘着斑复合物的一部分和/或与细胞骨架的组分物理相互作用而有助于细胞迁移。本文概述了许多离子转运机制如何促进细胞运动的各种模式。© 2013美国生理学会。Compr Physiol 3：59 - 119，2013。
Cell motility is an essential feature of life. It is essential for reproduction, propagation, embryonic development, and healing processes such as wound closure and a successful immune defense. If out of control, cell motility can become life‐threatening as, for example, in metastasis or autoimmune diseases. Regardless of whether ciliary/flagellar or amoeboid movement, controlled motility always requires a concerted action of ion channels and transporters, cytoskeletal elements, and signaling cascades. Ion transport across the plasma membrane contributes to cell motility by affecting the membrane potential and voltage‐sensitive ion channels, by inducing local volume changes with the help of aquaporins and by modulating cytosolic Ca2+and H+concentrations. Voltage‐sensitive ion channels serve as voltage detectors in electric fields thus enabling galvanotaxis; local swelling facilitates the outgrowth of protrusions at the leading edge while local shrinkage accompanies the retraction of the cell rear; the cytosolic Ca2+concentration exerts its main effect on cytoskeletal dynamics via motor proteins such as myosin or dynein; and both, the intracellular and the extracellular H+concentration modulate cell migration and adhesion by tuning the activity of enzymes and signaling molecules in the cytosol as well as the activation state of adhesion molecules at the cell surface. In addition to the actual process of ion transport, both, channels and transporters contribute to cell migration by being part of focal adhesion complexes and/or physically interacting with components of the cytoskeleton. The present article provides an overview of how the numerous ion‐transport mechanisms contribute to the various modes of cell motility. © 2013 American Physiological Society.Compr Physiol3:59‐119, 2013.
登录
查看更多内容
影响因子：
3.7
作者：
Betapudi V;Rai V;Beach JR;Egelhoff T
通讯作者：
Egelhoff T
中电导Ca2激活K通道在子宫内膜癌中过度表达并参与调节子宫内膜癌细胞的增殖。
DOI：
--
发表时间：
2007
期刊：
Zhonghua fu chan ke za zhi
影响因子：
--
作者：
Zhen;You;Min Su;X. Yi
通讯作者：
X. Yi
影响因子：
3.4
作者：
Yang, H.;Wang, Z.;Capo-Aponte, J. E.;Zhang, F.;Pan, Z.;Reinach, P. S.
通讯作者：
Reinach, P. S.
大鼠海马培养星形胶质细胞的细胞内 pH 调节
DOI：
--
发表时间：
1997
期刊：
The Journal of General Physiology
影响因子：
--
作者：
M. O. Bevensee;R. A. Weed;W. Boron
通讯作者：
W. Boron
影响因子：
2.4
作者：
del Monaco, Silvana M.;Marino, Gabriela I.;Kotsias, Basilio A.
通讯作者：
Kotsias, Basilio A.