The Association of Obesity, Type 2 Diabetes, and Hypertension with Severe Coronavirus Disease 2019 on Admission Among Mexican Patients
The Association of Obesity, Type 2 Diabetes, and Hypertension with Severe Coronavirus Disease 2019 on Admission Among Mexican Patients
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DOI：
10.1002/oby.22946
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发表时间：
2020-08-27
期刊：
影响因子：
6.9
通讯作者：
Barquera, Simon
中科院分区：
文献类型：
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作者：
Denova-Gutierrez, Edgar;Lopez-Gatell, Hugo;Barquera, Simon
目的探讨入院时肥胖、2型糖尿病和高血压与严重冠状病毒病2019 （COVID-19）的关系。方法在本研究中，墨西哥流行病学诊断和参考研究所的一个实验室对23,593例患者样本进行了评估。其中，新冠病毒阴性18443例，新冠病毒阳性3844例，其他呼吸道病毒阳性1306例。严重类型的呼吸系统疾病被定义为存在肺炎和其他需要重症监护的器官衰竭。采用多变量logistic回归模型探讨入院时重症COVID-19的相关因素。结果新冠肺炎检测阳性患者的肥胖（17.4%）、糖尿病（14.5%）和高血压（18.9%）比例高于未确诊患者。与非肥胖患者相比，肥胖患者入院时发生严重新冠肺炎的几率高1.43倍，而糖尿病和高血压患者入院时发生严重新冠肺炎的几率分别高1.87倍和1.77倍。结论入院时肥胖、糖尿病和高血压与重症COVID-19显著相关，年龄< 50岁的患者肥胖相关性更强。
Objective This study's aim was to explore the association of obesity, type 2 diabetes, and hypertension with severe coronavirus disease 2019 (COVID-19) on admission. Methods In the present study, a total of 23,593 patient samples were evaluated by a laboratory from the Mexican Institute of Epidemiological Diagnosis and Reference. Of these, 18,443 were negative for COVID-19, 3,844 were positive for COVID-19, and 1,306 were positive for other respiratory viruses. Severe types of respiratory disease were defined by the presence of pneumonia and other organ failure that requires intensive care. Multivariable logistic regression models were used to explore factors associated with severe COVID-19 on admission. Results Patients who tested positive for COVID-19 had a higher proportion of obesity (17.4%), diabetes (14.5%), and hypertension (18.9%) compared with those without a confirmed diagnosis. Compared with patients without obesity, those with obesity showed a 1.43-fold higher odds of developing severe COVID-19 on admission, whereas subjects with diabetes and hypertension showed a 1.87-fold and 1.77-fold higher odds of developing severe COVID-19 on admission, respectively. Conclusions Obesity, diabetes, and hypertension were significantly associated with severe COVID-19 on admission and the association of obesity was stronger in patients < 50 years of age.