Oxidative Stress and ADHD: A Meta-Analysis
Oxidative Stress and ADHD: A Meta-Analysis
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DOI：
10.1177/1087054713510354
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发表时间：
2015-11-01
影响因子：
3
通讯作者：
Faraone, Stephen V.
中科院分区：
文献类型：
--
作者：
Joseph, Nidhin;Zhang-James, Yanli;Faraone, Stephen V.
目的：探讨氧化应激和抗氧化活性在注意缺陷多动障碍（ADHD）中的作用。方法：我们研究了ADHD和氧化应激之间的关系，采用随机效应荟萃分析研究了药物治疗的ADHD患者和对照组的氧化应激和抗氧化状态。结果：6项研究共231例ADHD患者和207例对照符合我们的选择标准。ADHD和抗氧化状态之间的关联不显着。我们发现ADHD和氧化应激之间存在显著相关性，这不能用发表偏倚来解释。校正研究内聚类后，显著相关性失去了显著性。没有一项观察结果可解释阳性结果。结论：鉴于研究数量较少，这些结果是初步的。他们认为ADHD患者有正常水平的抗氧化剂产生，但他们对氧化应激的反应不足，导致氧化损伤。
Objective: To clarify the role of oxidative stress and antioxidant activity in ADHD. Method: We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls. Results: Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result. Conclusion: These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage.