Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography
Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography
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DOI：
10.1038/sj.eye.6701896
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发表时间：
2006-04-01
期刊：
影响因子：
3.9
通讯作者：
Varma, R
中科院分区：
文献类型：
--
作者：
Skaf, M;Bernardes, AB;Varma, R
目的建立4例正常人视网膜神经纤维层（RNFL）厚度的第三代光学相干断层扫描（OCT）径向轮廓，并与以往报道的组织学测量结果进行比较。将圆形扫描调整到视神经盘的尺寸，并以该半径进行三次扫描，此后每200 μ m进行一次扫描，直到1400 μ m的距离。四个不同的径向截面（颞上，鼻上，鼻下，颞下）进行了研究，以建立RNFL厚度OCT配置文件。结果RNFL厚度的象限位置和距视盘边缘的距离相互作用有显著性差异（P <0.001），象限位置和距视盘边缘的距离相互作用有显著性差异（P <0.001）。随着距椎间盘边缘距离的增加，RNFL厚度逐渐减小（P <0.001）。OCT内置软件自动生成的测量值比接近椎间盘边缘的组织学测量值薄（P <0.001）。结论建立了4个正常OCT RNFL轮廓，并与同一区域的组织学数据进行了比较。OCT 3评估的RNFL测量值在靠近视盘边缘处明显变薄。
Aims To establish four normal retinal nerve fibre layer (RNFL) thickness radial profiles based on third-generation optical coherence tomography (OCT) and to compare them with previously reported histologic measurements.Methods A total of 20 normal eyes were studied. A circular scan was adjusted to the size of the optic disc and three scans were performed with this radius and every 200 mu m thereafter, up to a distance of 1400 mu m. Four different radial sections (superotemporal, superonasal, inferonasal, and inferotemporal) were studied to establish RNFL thickness OCT profiles. Additionally, two radial scans orientated at 45 and 1351 crossing the optic disc centre were performed in six of 20 eyes, and RNFL thickness was measured at disc margin.Results Quadrant location and distance from disc margin interaction in RNFL thickness was statistically significant (P < 0.001). The RNFL thickness decreased (P < 0.001) as the distance from the disc margin increased for all sections. The measurements automatically generated by the OCT built-in software were thinner (P < 0.001) than histologic ones close to the disc margin.Conclusions Four normal OCT RNFL profiles were established and compared with histological data obtained from the same area. RNFL measurements assessed by OCT 3 were significantly thinner close to the optic disc margin.