LocSigDB: a database of protein localization signals.
LocSigDB: a database of protein localization signals.
复制标题
DOI：
10.1093/database/bav003
复制
发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Guda, Chittibabu
中科院分区：
文献类型：
--
作者：
Negi, Simarjeet;Pandey, Sanjit;Guda, Chittibabu
LocSigDB（http：//genome.unmc.edu/LocSigDB/）是针对八个不同的亚细胞位置的实验蛋白定位信号的手动策划的数据库;主要在具有细菌蛋白的简短覆盖的真核细胞中。蛋白质必须定位于其适当的亚细胞区室以执行其所需的功能。蛋白质错误定位到非预期位置是许多人类疾病的致病因素;因此，收集已知的分选信号将有助于支持许多重要的生物医学研究领域。通过进行广泛的文献研究，我们汇编了533个实验确定的定位信号的集合，沿着具有这种信号的蛋白质。LocSigDB中的每个信号都注释有其定位、来源、PubMed参考文献，并与UniProt数据库中的蛋白质以及含有与给定信号相同氨基酸模式的生物体信息沿着链接。从LocSigDB网络服务器，用户可以下载整个数据库或使用直观的查询界面浏览/搜索数据。到目前为止，LocSigDB是八个不同亚细胞位置的蛋白质定位信号的最全面的纲要。数据库URL：http://genome.unmc.edu/LocSigDB/
LocSigDB (http://genome.unmc.edu/LocSigDB/) is a manually curated database of experimental protein localization signals for eight distinct subcellular locations; primarily in a eukaryotic cell with brief coverage of bacterial proteins. Proteins must be localized at their appropriate subcellular compartment to perform their desired function. Mislocalization of proteins to unintended locations is a causative factor for many human diseases; therefore, collection of known sorting signals will help support many important areas of biomedical research. By performing an extensive literature study, we compiled a collection of 533 experimentally determined localization signals, along with the proteins that harbor such signals. Each signal in the LocSigDB is annotated with its localization, source, PubMed references and is linked to the proteins in UniProt database along with the organism information that contain the same amino acid pattern as the given signal. From LocSigDB webserver, users can download the whole database or browse/search for data using an intuitive query interface. To date, LocSigDB is the most comprehensive compendium of protein localization signals for eight distinct subcellular locations. Database URL: http://genome.unmc.edu/LocSigDB/