Bioconcentration, depuration and toxicity of Pb in the presence of titanium dioxide nanoparticles in zebrafish larvae
Bioconcentration, depuration and toxicity of Pb in the presence of titanium dioxide nanoparticles in zebrafish larvae
复制标题
二氧化钛纳米颗粒存在下斑马鱼幼虫体内 Pb 的生物富集、净化和毒性
DOI：
10.1016/j.aquatox.2019.105257
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发表时间：
2019
影响因子：
4.5
通讯作者：
Wu Hongjuan
中科院分区：
文献类型：
--
作者：
Hu Shengchao;Han Jian;Yang Lihua;Li Sen;Guo Yongyong;Zhou Bingsheng;Wu Hongjuan
The interactions between nanoparticles (NPs) and metals in aquatic environments may modify the bioavailability and toxicity of metals to organisms. In this study, we investigated the effects of titanium dioxide NPs (n-TiO2) on the bioconcentration, depuration, and neurotoxic effects of lead (Pb) in zebrafish larvae. Transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy showed that Pb2+was adsorbed by n-TiO2to form NP–Pb complexes in suspension, and these complexes were observed in larval tissues. The bioconcentration of Pb in larvae along with the depuration rates of Pb were higher in the presence of n-TiO2compared to when n-TiO2was absent. Exposure to Pb alone induced the expression of the biomarker metallothionein, downregulated neurodevelopment-related genes, and reduced swimming activity of larvae. However, the addition of n-TiO2to the exposure solution alleviated these effects. The results suggest that n-TiO2can act as a carrier of Pb to increase its bioconcentration; however, the formation of NP–Pb complexes likely reduces the amount of free Pb2+, thereby reducing toxicity to larvae.
