Clinicopathologic Characteristics of T-cell Non-Hodgkin's Lymphoma: A Single Institution Experience
Clinicopathologic Characteristics of T-cell Non-Hodgkin's Lymphoma: A Single Institution Experience
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DOI：
10.3904/kjim.2009.24.2.128
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发表时间：
2009-06-01
影响因子：
2.4
通讯作者：
Suh, Cheolwon
中科院分区：
文献类型：
--
作者：
Ko, Ock Bae;Lee, Dae Ho;Suh, Cheolwon
背景/目标：虽然T细胞非霍奇金淋巴瘤（NHL）的发病率在远东亚洲高于西方国家，但其在韩国的发病率和临床病程尚不明确。因此，我们评估的相对频率和临床特征的T细胞NHL在Korea.Methods：我们进行了回顾性分析的586例NHL患者。最常见的T细胞NHL亚型为鼻型结性NK/T细胞淋巴瘤（NASAL）、未特指型外周T细胞淋巴瘤（PTCL-U）和原发性系统性T/空细胞间变性大细胞淋巴瘤（ALCL）。7种病理亚型可分为3个预后亚组。当三种最常见亚型的患者被分组在一起时，他们的生存率反映在国际预后指数（IPI）评分中。单因素分析IPI因素和其他临床特征表明，临床分期和结节部位是生存的显着预测因子。考克斯多变量分析表明，结节部位的数量是唯一的独立预后indicator.Conclusions：T细胞NHL的相对频率似乎在韩国下降，虽然鼻黏膜活检仍然频繁。韩国ALCL患者似乎预后不良。大规模的研究是必要的韩国T细胞NHL患者。（Korean J Intern Med 2009;24：128-134）
Background/Aims: Although the incidence of T-cell non-Hodgkin's lymphoma (NHL) is higher in Far East Asia than in Western countries, its incidence and clinical course in Korea are not well-defined. Therefore, we assessed the relative frequency and clinical features of T-cell NHL in Korea.Methods: We performed a retrospetcive analysis of 586 patients with NHL.Results: 101 (17.2%) had T-cell NHL. The most frequent subtypes of T-cell NHL were extranodal NK/T-cell lymphoma, nasal type (NASAL), peripheral T-cell lymphoma, unspecified type (PTCL-U), and anaplastic large cell lymphoma, T/null cell, primary systemic type (ALCL). The seven pathological subtypes could be classified into three prognostic subgroups. When patients with the three most frequent subtypes were grouped together, their survival was reflected in the International Prognostic Index (IPI) scores. Univariate analysis of IPI elements and other clinical features showed that clinical stage and extranodal sites were significant predictors of survival. Cox multivariate analysis showed that the number of extranodal sites was the only independent prognostic indicator.Conclusions: The relative frequency of T-cell NHL seems to be decreasing in Korea, although NASAL remains frequent. Korean patients with ALCL appear to have an unfavorable prognosis. Large-scale studies are warranted for Korean patients with T-cell NHL. (Korean J Intern Med 2009;24:128-134)