Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal-Free Conditions
Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal-Free Conditions
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DOI：
10.1021/ol300166q
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发表时间：
2012-03-16
期刊：
影响因子：
5.2
通讯作者：
Chang, Sukbok
中科院分区：
文献类型：
--
作者：
Kim, Hyun Jin;Cho, Seung Hwan;Chang, Sukbok
以二乙酸碘苯为氧化剂，卤化物为添加剂，在室温下，通过烯烃的分子内氧化二胺化反应合成了双吲哚啉。该反应具有反应条件温和、底物范围广、官能团耐受性好等特点。相同的方案成功地扩展到氨羟基化。
A metal-free procedure that is simple to operate and convenient to handle was developed for the facile intramolecular oxidative diamination of olefins using an iodobenzene diacetate oxidant and a halide additive to furnish bisindolines at room temperature. The present reaction is featured by mild conditions, a broad substrate scope, and excellent functional group tolerance. The same protocol was successfully extended to the aminohydroxylation.