Lambda Ig constant region genes are translocated to chromosome 8 in Burkitt's lymphoma with t(8;22).
Lambda Ig constant region genes are translocated to chromosome 8 in Burkitt's lymphoma with t(8;22).
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伯基特淋巴瘤中 Lambda Ig 恒定区基因易位至 8 号染色体，带有 t(8;22)。
DOI：
10.1093/nar/11.4.1133
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发表时间：
1983
影响因子：
14.9
通讯作者：
J. Kaplan
中科院分区：
文献类型：
--
作者：
A. de la Chapelle;G. Lenoir;J. Boué;A. Boué;P. Gallano;C. Huerre;M. Szajnert;M. Jeanpierre;J. Lalouel;J. Kaplan
用克隆的免疫球蛋白基因探针对正常人染色体进行原位杂交，优先标记22q11条带。在两个来源于Burkitt淋巴瘤的t（8;22）细胞系中，在8q+染色体衍生物上发现了强烈的信号，表明lambda Ig基因簇的恒定区从22号染色体易位到8号染色体。此外，在22q-衍生染色体上观察到的信号在两株细胞系中有一株比背景强，而在另一株则没有。这意味着，在某些情况下，22号染色体的断点位于Ig基因本身或这些基因簇之间，并且不同的情况有不同的断点。
By in situ hybridization of normal human chromosomes with a cloned genomic probe specific for the constant region of the lambda immunoglobulin genes, band 22q11 was preferentially labelled. In two cell lines with t(8;22) derived from Burkitt's lymphoma a strong signal was noted on the 8q+ chromosome derivative, indicating that the constant region of the lambda Ig gene cluster was translocated from chromosome 22 to chromosome 8. In addition, the signal observed on the 22q- derivative chromosome was stronger than the background in one of the two cell lines tested, but not in the other. The implications are that the break point in chromosome 22 in some cases lies within the Ig gene itself or between clusters of such genes, and that different cases have different break points.