Enhanced hydrogel adhesion by polymer interdiffusion: use of linear poly(ethylene glycol) as an adhesion promoter.
Enhanced hydrogel adhesion by polymer interdiffusion: use of linear poly(ethylene glycol) as an adhesion promoter.
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DOI：
10.1163/156856297x00362
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. J. Sahlin-J.;N. Peppas
中科院分区：
文献类型：
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作者：
J. J. Sahlin-J.;N. Peppas
研究了分离水凝胶膜层所需的断裂能，以评估本体聚合物扩散对水凝胶/水凝胶粘附的影响，并获得聚合物粘膜粘附中断裂能的分子信息。将聚（乙二醇）（PEG）掺入水凝胶中并用作粘合促进剂。PEG分子量和接触时间对PEG在水凝胶/水凝胶界面扩散的影响进行了研究，通过使用张力研究和近场FTIR显微镜。这些实验表明，线性PEG扩散增强了两个水凝胶层之间的粘附。不能单独用表面润湿现象来解释增强的粘附力。这些结果表明，掺入聚合物网络（水凝胶）中的线性聚合物如PEG（粘附促进剂）的本体扩散是用于在各种应用中增强凝胶/凝胶粘附的有效技术，所述应用包括粘膜粘附中的聚合物/粘液相互作用和粘膜粘附控制的药物递送系统的开发。
The fracture energy required to separate layers of hydrogel films was investigated to evaluate the impact of bulk polymer diffusion on hydrogel/hydrogel adhesion and to obtain molecular information on the fracture energy in polymer mucoadhesion. Poly(ethylene glycol) (PEG) was incorporated in a hydrogel and was used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/hydrogel interface was investigated by using tensiometric studies and near-field FTIR microscopy. These experiments indicated that linear PEG diffusion enhanced the adhesion between the two hydrogel layers. The enhanced adhesion could not be explained by surface wetting phenomena alone. These results indicated that bulk diffusion of linear polymers such as PEG (adhesion promoter) incorporated into polymer networks (hydrogels) was an effective technique for enhancing gel/gel adhesion in various applications including polymer/mucus interactions in mucoadhesion and development of mucoadhesive controlled drug delivery systems.