The TGF-β Signalling Network in Muscle Development, Adaptation and Disease
The TGF-β Signalling Network in Muscle Development, Adaptation and Disease
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DOI：
10.1007/978-3-319-27511-6_5
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Harrison, Craig A.
中科院分区：
文献类型：
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作者：
Chen, Justin L.;Colgan, Timothy D.;Harrison, Craig A.
骨骼肌在生理刺激下具有显著的改变大小和发力能力的能力。在病理状态下，控制这些属性的细胞过程的损伤也会影响肌肉质量和功能。肌生长抑制素是tgf - β家族的一员，已被确定为成年期肌肉发育和适应的关键调节因子。在肌肉中，肌生长抑制素与其I型（ALK4/5）和II型（ActRIIA/B）受体结合，启动Smad2/3信号传导和调节靶基因，协调蛋白质合成和降解之间的平衡。有趣的是，有证据表明，其他tgf - β蛋白与肌肉生长抑制素协同作用，调节骨骼肌的生长和重塑。因此，tgf - β蛋白及其相关信号成分的失调越来越多地与慢性疾病、衰老和不活动相关的肌肉萎缩有关。本文综述了对肌肉中tgf - β生物学的日益了解，以及其促进肌肉相关疾病治疗发展的潜力。
Skeletal muscle possesses remarkable ability to change its size and force-producing capacity in response to physiological stimuli. Impairment of the cellular processes that govern these attributes also affects muscle mass and function in pathological conditions. Myostatin, a member of the TGF-beta family, has been identified as a key regulator of muscle development, and adaptation in adulthood. In muscle, myostatin binds to its type I (ALK4/5) and type II (ActRIIA/B) receptors to initiate Smad2/3 signalling and the regulation of target genes that co-ordinate the balance between protein synthesis and degradation. Interestingly, evidence is emerging that other TGF-beta proteins act in concert with myostatin to regulate the growth and remodelling of skeletal muscle. Consequently, dysregulation of TGF-beta proteins and their associated signalling components is increasingly being implicated in muscle wasting associated with chronic illness, ageing, and inactivity. The growing understanding of TGF-beta biology in muscle, and its potential to advance the development of therapeutics for muscle-related conditions is reviewed here.