Structure and organization of paramyxovirus particles.

Structure and organization of paramyxovirus particles.
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DOI:
10.1016/j.coviro.2017.05.004
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发表时间:
2017-06
影响因子:
5.9
通讯作者:
Plemper RK
Plemper RK
中科院分区:
医学2区
文献类型:
--
作者:
Cox RM;Plemper RK

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副粘病毒家族包括主要的人类和动物病原体,如麻疹病毒(MeV)、腮腺炎病毒(MuV)、副流感病毒、新城疫病毒(NDV)以及高致病性人畜共患亨德拉病毒(HeV)和尼帕病毒(NiV)。副粘病毒颗粒是多形性的,具有脂质包膜,负极性的非片段RNA基因组,病毒粒子表面密集排列的糖蛋白。许多不同副粘病毒蛋白质和蛋白质片段的晶体结构已被解决,但有关整体病毒粒子组织的可用信息仍然有限。然而,最近的研究报道了基于低温电子断层扫描的仙台病毒(SeV)、MeV、NDV和人副流感病毒3型(HPIV3)颗粒的重建和niv衍生的病毒样颗粒(VLPs)的表面评估,这些研究提出了关于副粘病毒颗粒组装、出芽和组织的创新假设。在总结了目前对副粘病毒病毒粒子形态的认识之后,本文将重点讨论这些粒子重建对副粘病毒组装和感染的现有模型的影响。
The paramyxovirus family comprises major human and animal pathogens such as measles virus (MeV), mumps virus (MuV), the parainfluenzaviruses, Newcastle disease virus (NDV), and the highly pathogenic zoonotic hendra (HeV) and nipah (NiV) viruses. Paramyxovirus particles are pleomorphic, with a lipid envelope, nonsegmented RNA genomes of negative polarity, and densely packed glycoproteins on the virion surface. A number of crystal structures of different paramyxovirus proteins and protein fragments were solved, but the available information concerning overall virion organization remains limited. However, recent studies have reported cryo-electron tomography-based reconstructions of Sendai virus (SeV), MeV, NDV, and human parainfluenza virus type 3 (HPIV3) particles and a surface assessment of NiV-derived virus-like particles (VLPs), which have yielded innovative hypotheses concerning paramyxovirus particle assembly, budding, and organization. Following a summary of the current insight into paramyxovirus virion morphology, this review will focus on discussing the implications of these particle reconstructions on the present models of paramyxovirus assembly and infection.
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