Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction
Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction
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DOI：
10.1016/j.pscychresns.2014.10.017
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发表时间：
2015-02-28
影响因子：
2.3
通讯作者：
Fusar-Poli, Paolo
中科院分区：
文献类型：
--
作者：
Frascarelli, Marianna;Tognin, Stefania;Fusar-Poli, Paolo
精神分裂症患者的执行功能持续受损，这与前额区灰质体积减少有关。前额叶脑区的缺失也与疾病持续时间有关。本研究的目的是探讨精神分裂症患者执行功能下降和慢性化对前额叶的影响。参与者包括33名精神分裂症患者，18名病程（Dol）短于10年，15名病程长于10年。另外，24名健康对照者作为对照组。参与者进行了威斯康星州卡片分类测试（WCST），并进行了结构磁共振成像。与健康对照组相比，Dol较长的患者左内侧额回灰质体积显着减少。此外，与病程较短的患者相比，病程较长的患者有更大的灰质体积减少的趋势。WCST上左额内侧回的体积表现之间没有交互作用。本研究支持这一假设，即额内侧回的改变在精神分裂症是敏感的病程。这些改变与执行功能无关。(C)2014爱思唯尔爱尔兰有限公司版权所有，
Executive functioning is consistently impaired in schizophrenia, and it has been associated with reduced gray matter volume in prefrontal areas. Abnormalities in prefrontal brain regions have also been related to the illness duration. The aim of the study was to investigate the effect of executive functioning decline and chronicity in prefrontal regions of patients with schizophrenia. Participants comprised 33 schizophrenic patients, 18 with duration of illness (Dol) shorter than 10 years and 15 with duration of illness longer than 10 years. In addition, 24 healthy controls served as a comparison group. Participants performed the Wisconsin Card Sorting Test (WCST) and underwent structural magnetic resonance imaging. Patients with longer Dol showed significant reduction of gray matter volume in the left medial frontal gyms compared with healthy controls. Moreover, there was a trend for greater gray matter volume decrease in patients with a longer illness duration compared with patients with shorter illness duration. There was no interaction between the volume of the left medial frontal gyms performance on the WCST. The present study supports the hypothesis that medial frontal gyrus alterations in schizophrenia are sensitive to duration of illness. These alterations were not associated with executive functioning. (C) 2014 Elsevier Ireland Ltd. All rights reserved,