Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish
Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish
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DOI：
10.1016/s1567-133x(03)00054-1
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发表时间：
2003-08-01
影响因子：
1.2
通讯作者：
Lescure, A
中科院分区：
文献类型：
--
作者：
Thisse, C;Degrave, A;Lescure, A
硒在脊椎动物胚胎发育中具有重要作用，但目前对大多数硒蛋白基因的表达模式和生物学功能知之甚少。以斑马鱼为模型，利用原位杂交技术对不同发育阶段的胚胎进行了硒蛋白基因表达的系统分析。21硒蛋白的mRNA进行了分析，他们都表现出的表达模式仅限于特定的组织。此外，我们证明了高度相似的硒蛋白旁系同源物在不同的领土内表达。因此，组织和发育特异性表达模式提供了新的信息未知功能的硒蛋白。(C)2003 Elsevier Science B.V.保留所有权利。
Selenium is important for embryogenesis in vertebrates but little is known about the expression patterns and biological functions of most selenoprotein genes. Taking advantage of the zebrafish model, systematic analysis of selenoprotein gene expression was performed by in situ hybridization on whole-mount embryos at different developmental stages. Twenty-one selenoprotein mRNAs were analyzed and all of them exhibited expression patterns restricted to specific tissues. Moreover, we demonstrated that highly similar selenoprotein paralogs were expressed within distinct territories. Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. (C) 2003 Elsevier Science B.V. All rights reserved.