Altered sleep architecture in children and adolescents with Down syndrome.
Altered sleep architecture in children and adolescents with Down syndrome.
复制标题
患有唐氏综合症的儿童和青少年的睡眠结构发生了改变。
DOI：
10.1002/ajmg.c.32073
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Klerman,ElizabethB
中科院分区：
文献类型：
--
作者：
Gardner,KellyJ;Wang,Wei;Klerman,ElizabethB
患有唐氏综合症（DS）的儿童可能会经历睡眠结构的变化（即，不同的睡眠阶段），然后影响清醒时的功能，包括学习，情绪和破坏性行为。为了设计和测试干预措施，重要的是要记录任何差异，在儿童与DS和没有共同发生的诊断，包括神经精神疾病的诊断和阻塞性睡眠呼吸暂停（OSA）。MethodsA回顾性队列研究进行了在马萨诸塞州总医院的儿童和青少年与DS谁经历了多导睡眠图（PSG）在2016年8月和2022年7月。从电子病历中收集的患者数据包括诊断、PSG时的年龄和PSG报告。统计分析包括非配对T检验，以检验年龄组内睡眠结构差异的假设，以及DS儿童与合并诊断之间的差异。单因素方差分析用于确定DS患者中OSA严重程度的统计学显著性。与规范数据相比，睡眠时间更少，清醒时间更多）。在这个队列中，同时诊断出自闭症会对睡眠结构产生进一步的负面影响。89%的DS诊断OSA，但只有那些严重的OSA经历了睡眠architecture.ConclusionAge的负面影响是一个重要的协变量时，研究儿童与DS和神经型儿童的睡眠。需要研究来测试最大限度地减少观察到的睡眠结构差异是否会转化为改善的学习，情绪和行为结果，以及治疗OSA如何影响睡眠结构。
ObjectiveChildren with Down syndrome (DS) may experience changes in sleep architecture (i.e., different sleep stages) that then affect waketime functioning, including learning, mood, and disruptive behavior. For designing and testing interventions, it is important to document any differences in sleep architecture in children with DS with and without co‐occurring diagnoses, including neuropsychiatric diagnoses and obstructive sleep apnea (OSA).MethodsA retrospective cohort study was performed at Massachusetts General Hospital for children and adolescents with DS who underwent polysomnography (PSG) between August 2016 and July 2022. Patient data collected from the electronic medical record included diagnoses, age at PSG, and PSG report. Statistical analysis included unpaired T tests to test hypotheses about differences in sleep architecture within age groups, and differences between children with DS and a co‐occurring diagnosis. One way ANOVA was used to determine statistical significance of OSA severity within patients with DS.ResultsWhen compared by age group, those with DS had negative changes in sleep architecture (e.g., less sleep and more wake) when compared to normative data. Within this cohort, having a co‐occurring diagnosis of autism resulted in further, negative effects on sleep architecture. 89% of those with DS had diagnosed OSA but only those with severe OSA experienced negative effects on sleep architecture.ConclusionAge is an important covariate when studying the sleep of children with DS and neurotypical children. Studies are needed to test whether minimizing the observed differences in sleep architecture will translate to improved learning, mood, and behavioral outcomes, and how treating OSA affects sleep architecture.