Cancer-protective properties of high-selenium broccoli
Cancer-protective properties of high-selenium broccoli
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DOI：
10.1021/jf0014821
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发表时间：
2001-05-01
影响因子：
6.1
通讯作者：
Whanger, PD
中科院分区：
文献类型：
--
作者：
Finley, JW;Ip, C;Whanger, PD
高硒大蒜中的硒（Se）可以降低化学诱导的乳腺肿瘤的发病率，高硒西兰花中的硒可以降低结肠癌的发病率。然而，高硒西兰花中的硒对预防乳腺癌的能力还没有经过测试。此外，花椰菜芽含有许多次生植物化合物，这些化合物已知可以降低癌症风险，但花椰菜芽的抗癌活性尚未得到调查。目前的研究检验了高硒西兰花或高硒西兰花芽防止化学诱导的乳腺癌或结肠癌的能力。在一项实验中，食用含有3.0杯硒/g的高硒西兰花的Sprague-Dawley大鼠的乳腺肿瘤明显少于食用含有或不添加普通西兰花的0.1杯硒作为亚硒酸盐的大鼠。在第二个实验中，喂食2.0杯硒/g高硒西兰花小花或高硒西兰花芽饲料的Fisher F-344大鼠的结肠隐窝异常明显少于喂食0.1或2杯硒/g添加或不添加低硒西兰花的亚硒酸盐饲料的大鼠。这些数据表明，高硒西兰花中硒的防癌作用延伸到乳腺癌，而西兰花对结肠癌的保护形式包括高硒西兰花芽。
Selenium (Se) from high-Se garlic reduces the incidence of chemically induced mammary tumors, and Se from high-Se broccoli reduces colon cancer. However, the ability of Se from high-Se broccoli to protect against mammary cancer has not been tested. Also, the sprout form of broccoli contains many secondary plant compounds that are known to reduce cancer risk, but the anticarcinogenic activity of broccoli sprouts has not been investigated. The present studies examined the ability of high-Se broccoli or high-Se broccoli sprouts to protect against chemically induced mammary or colon cancer. In one experiment, Sprague-Dawley rats that consumed diets containing 3.0 mug of Se/g supplied as high-Se broccoli had significantly fewer mammary tumors than rats fed 0.1 mug of Se as selenite with or without the addition of regular broccoli. In the second experiment, Fisher F-344 rats fed 2.0 mug of Se/g of diet supplied as either high-Se broccoli florets or high-Se broccoli sprouts had significantly fewer aberrant colon crypts than rats fed 0.1 or 2 mug of Se/g of diet supplied as selenite with or without the addition of low-Se broccoli. These data demonstrate that the cancer-protective effect of Se in high-Se broccoli extends to mammary cancer and the protective forms of broccoli against colon cancer include high-Se broccoli sprouts.