All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery
All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery
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DOI：
10.1002/anie.200805998
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Cheon, Jinwoo
中科院分区：
文献类型：
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作者：
Lee, Jae-Hyun;Lee, Kyuri;Cheon, Jinwoo
利用磁性纳米颗粒平台（MEIO，磁性工程氧化铁）观察到癌细胞靶向基因沉默，该平台上连接有荧光染料，siRNA和RGD肽靶向部分（见图片）。不同的功能使得能够对靶细胞进行宏观（磁共振）和微观（荧光）成像。该系统可适用于同时的诊断和治疗应用。
Cancer‐cell‐targeted gene silencingwas observed with a magnetic‐nanoparticle platform (MEIO, magnetism‐engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD‐peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.