Visible-light-induced trifluoromethylation of N-aryl acrylamides: a convenient and effective method to synthesize CF(3)-containing oxindoles bearing a quaternary carbon center.
Visible-light-induced trifluoromethylation of N-aryl acrylamides: a convenient and effective method to synthesize CF(3)-containing oxindoles bearing a quaternary carbon center.
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DOI：
10.1002/chem.201302407
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发表时间：
2013-10
期刊：
影响因子：
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通讯作者：
Pan Xu;Jin Xie;Qicai Xue;C. Pan;Yixiang Cheng;Chengjian Zhu
中科院分区：
文献类型：
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作者：
Pan Xu;Jin Xie;Qicai Xue;C. Pan;Yixiang Cheng;Chengjian Zhu
三氟甲基化/芳基化：n -芳基丙烯酰胺在钌光催化剂存在下，以Togni试剂作为CF3源，进行可见光诱导的串联三氟甲基化/芳基化。该反应是一种高效且环保的合成方法，可用于制备多种含CF3的含季碳中心的氧吲哚。
Trifluoromethylation/arylation: N-aryl acrylamides undergo visible-light-induced tandem trifluoromethylation/arylation in the presence of a ruthenium photocatalyst with Togni's reagent as the CF3 source. This reaction serves as a powerful and ecofriendly synthetic method for the preparation of a variety of CF3 -containing oxindoles bearing a quaternary carbon center.