The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
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DOI：
10.1007/s00439-009-0768-9
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发表时间：
2010-03-01
期刊：
影响因子：
5.3
通讯作者：
Ohashi, Jun
中科院分区：
文献类型：
--
作者：
Furusawa, Takuro;Naka, Izumi;Ohashi, Jun
在过去的几十年里，各种太平洋岛屿人口的肥胖率都出现了显著的增长。本研究调查了太平洋岛民瘦素基因启动子G-2548A(Rs7799039)和瘦素受体基因(LEPR)两个非同义单核苷酸多态K109R(Rs1137100)和Q223R(Rs1137101)与体重、体重指数(BMI)和肥胖(BMI a/1000日元30)的关系。在调整了年龄、性别和人口差异后，对745名讲南岛语(AN)的参与者进行了分析。结果显示，223Q等位基因携带者的体重(P=0.0009)和体重指数(P=0.0022)显著高于非携带者(即223R纯合子)，而且223Q携带者的肥胖风险也显著高于非携带者(P=0.0222)。另外两个基因G-2548A和K109R与体重、BMI和肥胖无关。223Q等位基因在讲安语人群中广泛存在，提示LEPR Q223R基因多态性是太平洋岛国人群肥胖率高的原因之一。
Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI a parts per thousand yen 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.