Syndecans: synergistic activators of cell adhesion
Syndecans: synergistic activators of cell adhesion
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DOI：
10.1016/s0962-8924(98)01244-6
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发表时间：
1998-05-01
影响因子：
19
通讯作者：
Couchman, JR
中科院分区：
文献类型：
--
作者：
Woods, A;Couchman, JR
细胞表面蛋白聚糖参与细胞粘附、生长因子信号传导、脂肪酶活性和抗凝。直到最近，仅研究了糖胺聚糖链的作用。现在，通过对几种核心蛋白的分子表征，每个蛋白聚糖种类在细胞信号传导途径中的作用正在被确定。这篇综述描述了我们对硫酸乙酰肝素蛋白聚糖主要跨膜基团多配体理解的一些最新进展，包括它们作为调节基于整合素的粘附的辅助信号分子发挥重要作用的证据。
Cell-surface proteoglycans participate in cell adhesion, growth-factor signalling, lipase activity and anticoagulation. Until recently, only the roles of the glycosaminoglycan chains were investigated. Now, with molecular characterization of several core proteins, the roles of each individual proteoglycan species in cellular signalling pathways are being determined. This review describes some of the recent advances in our understanding of the major transmembrane group of heparan sulfate proteoglycans, the syndecans, including evidence that they play an important role as accessory signalling molecules modulating integrin-based adhesion.