Sleep disruption in spinocerebellar ataxia type 3: A genetic and polysomnographic study
Sleep disruption in spinocerebellar ataxia type 3: A genetic and polysomnographic study
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DOI：
10.1016/j.jcma.2012.09.006
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发表时间：
2013-01-01
影响因子：
3
通讯作者：
Soong, Bing-Wen
中科院分区：
文献类型：
--
作者：
Chi, Nai-Fang;Shiao, Guang-Ming;Soong, Bing-Wen
背景：神经退行性疾病患者存在睡眠结构紊乱和快速眼动(REM)睡眠行为障碍(RBD)。方法：对15例脊髓小脑型共济失调患者和16例健康对照组进行临床病史、国际合作共济失调评定量表(ICARS)、Epworth嗜睡量表(ESS)和多导睡眠图的评估。结果：SCA3患者的睡眠效率和REM睡眠百分比降低，且与ICCARS的严重程度呈负相关。REM睡眠减少与RBD无关，严重的REM睡眠减少可能会显著干扰RBD的评估。结论：SCA3患者随着疾病的发展，睡眠效率低下和REM睡眠异常是睡眠结构紊乱的特征。SCA3患者睡眠时呼吸紊乱或日间过度嗜睡的发生率与对照组相比无显著差异。版权所有(C)2012爱思唯尔台湾有限责任公司和中华医学会。版权所有。
Background: Sleep structure disruption and rapid eye movement (REM) sleep behavior disorders (RBD) have been previously reported in patients with neurodegenerative diseases. However, similar studies have rarely been quantitatively conducted in type 3 spinocerebellar ataxia (SCA3).Methods: Fifteen patients with SCA3 and 16 healthy controls were recruited and evaluated by clinical history, International Cooperative Ataxia Rating Scale (ICARS), Epworth sleepiness scale (ESS), and polysomnography.Results: Patients with SCA3 had reductions in sleep efficiency and percentage of REM sleep, which were negatively correlated with the severity of ataxia as evaluated by ICARS. REM sleep reduction occurred regardless of the presence of RBD, and severe reduction of REM sleep may significantly disturb the assessment of RBD.Conclusion: Poor sleep efficiency and REM sleep aberrations are the characteristics of sleep structure disruption in SCA3 as the disease progresses. The incidence of respiratory disturbance during sleep or excessive daytime sleepiness was not significantly higher in SCA3 patients than controls. Copyright (C) 2012 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.