Leukocyte-endothelial adhesion molecules.
Leukocyte-endothelial adhesion molecules.
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DOI：
10.1182/blood.v84.7.2068.bloodjournal8472068
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发表时间：
1994-10
期刊：
影响因子：
20.3
通讯作者：
T. Carlos;J. Harlan
中科院分区：
文献类型：
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作者：
T. Carlos;J. Harlan
在9年以来的最后审查白细胞和内皮细胞的相互作用发表在这本杂志上的许多关键结构参与白细胞粘附和迁移的内皮细胞已经阐明。随着细胞和分子生物学方法的出现，研究已经从早期的活体显微镜和组织学描述，粘附分子的功能和免疫学表征，现在的发展，遗传缺陷动物和第一个阶段的“抗粘附”治疗在人类的I期试验。白细胞整合素、IG基因超家族的内皮成员和选择素的粘附功能的分子克隆和定义已经为构建白细胞迁移的分子基础的操作范例提供了足够的信息。这些粘附分子的调节，由趋化因子，细胞因子，或趋化因子，和粘附途径的相互关系，需要在体外，特别是在体内进行检查。需要进一步的研究来剖析单个粘附分子在各种炎症或免疫反应模型中对白细胞迁移的贡献。当然，新的粘附结构将被确定，目前的白细胞迁移的范例将被完善。对炎症和免疫反应的生物学和病理学的新见解的承诺，以及对各种疾病的新疗法的潜力，确保了这将继续是一个令人兴奋的研究领域。
In the 9 years since the last review on leukocyte and endothelial interactions was published in this journal many of the critical structures involved in leukocyte adherence to and migration across endothelium have been elucidated. With the advent of cell and molecular biology approaches, investigations have progressed from the early descriptions by intravital microscopy and histology, to functional and immunologic characterization of adhesion molecules, and now to the development of genetically deficient animals and the first phase I trial of "anti-adhesion" therapy in humans. The molecular cloning and definition of the adhesive functions of the leukocyte integrins, endothelial members of the Ig gene superfamily, and the selectins has already provided sufficient information to construct an operative paradigm of the molecular basis of leukocyte emigration. The regulation of these adhesion molecules by chemoattractants, cytokines, or chemokines, and the interrelationships of adhesion pathways need to be examined in vitro and, particularly, in vivo. Additional studies are required to dissect the contribution of the individual adhesion molecules to leukocyte emigration in various models of inflammation or immune reaction. Certainly, new adhesion structures will be identified, and the current paradigm of leukocyte emigration will be refined. The promise of new insights into the biology and pathology of the inflammatory and immune response, and the potential for new therapies for a wide variety of diseases assures that this will continue to be an exciting area of investigation.