Applying a new technology to an old question: whole-genome sequencing and Staphylococcus aureus acquisition in an intensive care unit.
Applying a new technology to an old question: whole-genome sequencing and Staphylococcus aureus acquisition in an intensive care unit.
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将新技术应用于一个老问题：在重症监护病房进行全基因组测序和金黄色葡萄球菌采集。
DOI：
10.1093/cid/cit812
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Daum,RobertS
中科院分区：
文献类型：
--
作者：
David,MichaelZ;Daum,RobertS
长期以来，金黄色葡萄球菌的表型和基因特征一直被用来确定从具有先前共同感染危险因素的流行病学证据的患者中获得的分离株的关联性。在20世纪40年代，在抗菌剂使用时代的黎明，对两个分离株的抗菌谱进行了比较，以表明分离株的相关性。在20世纪50年代，葡萄球菌噬菌体分型系统[1，2]经常使疫情调查中的感染控制从业者能够将菌株彼此联系起来。例如，随着医院中的噬菌体分型，一种被称为噬菌体80/81的毒力和迅速传播的金黄色葡萄球菌菌株类型被识别和跟踪[3]。
Phenotypic and genotypic characteristics of Staphylococcus aureus have long been used to determine the relatedness of isolates obtained from patients with epidemiologic evidence of a prior common risk factor for infection. In the 1940s, at the dawn of the era of the use of antimicrobial agents, the antibiogram of 2 isolates was compared to suggest isolate relatedness. In the 1950s, staphylococcal bacteriophage typing systems [1, 2] often enabled infection control practitioners in outbreak investigations to relate strains to one another. For example, with phage typing in hospitals, a virulent and rapidly disseminated S. aureus strain type known as the phage 80/81 type was recognized and tracked [3].