Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton from Aspergillus terreus
Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton from Aspergillus terreus
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Terreuspyridine：一种来自土曲霉的意外吡啶稠合半萜类生物碱，具有四环 6/6/6/6 骨架
DOI：
10.1021/acs.orglett.0c02641
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发表时间：
2020-09-04
期刊：
影响因子：
5.2
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Li, Huaqiang;Feng, Wenya;Zhang, Yonghui
Terreuspyridine(1)是从真菌Terreus中分离得到的第一个3，5-去甲基麦穗酸(DMOA)类化合物，代表了一种新型的具有意外的四环6/6/6/6结构的硫代萜类生物碱。用X-射线衍射法确定了1的绝对构型。在生物遗传学上，它被认为是由DMOA-硫代萜类化合物和谷氨酸融合而来的。叔丁基吡啶(1)对BChE有中等的抑制活性，IC50值为16.4 mU/M。
Terreuspyridine (1), the first 3,5-demethylorsellinic acid (DMOA) derived meroterpenoid alkaloid, was isolated from the fungus Aspergillus terreus, which represents a new type of meroterpenoid possessing an unexpected tetracyclic 6/6/6/6 architecture. The structure of 1 with absolute configuration was determined by X-ray diffraction analysis. Biogenetically, it was proposed to be derived from the fusion of a DMOA-meroterpenoid and a glutamate. Terreuspyridine (1) exhibited moderate inhibitory activity against the BChE with an IC50 value of 16.4 mu M.