Economic Analysis of Vaccination Strategies for PRRS Control
Economic Analysis of Vaccination Strategies for PRRS Control
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DOI：
10.1371/journal.pone.0144265
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发表时间：
2015-12-16
期刊：
影响因子：
3.7
通讯作者：
Morrison, Robert B.
中科院分区：
文献类型：
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作者：
Linhares, Daniel C. L.;Johnson, Clayton;Morrison, Robert B.
猪繁殖与呼吸综合征病毒(PRRSV)是一种猪特有的病原体，可导致生产成本的显著增加。当繁殖的猪群受到感染时，为了加速控制和消除PRRSV，一些兽医采取了一种名为Load-Close-Exposure的策略，包括在几周内中断将替换猪引入牛群(牛群关闭)，并将整个牛群暴露在复制的PRRSV下，以提高牛群的免疫力。使用改良活病毒(MLV)疫苗或野毒活疫苗(FVI)。这项研究包括部分预算分析，以比较MLV和FVI作为控制和消除受感染种群PRRSV的负载-密切接触方案的暴露方法，并对预防接种母猪群的效益/成本进行估计。在这项研究中使用的假设下，MLV比FVI具有经济优势。然而，敏感性分析显示，将利润率降至可变成本低于47.32美元，或将PRRSV归因性成本增加至18.89美元以上，或在25周前实现稳定时间，将导致FVI优于MLV。当PRRSV感染频率至少每2.1年一次时，对母猪群进行预防性疫苗接种是有益的。预防性疫苗接种的经济性受生长猪的野生型PRRSV感染的成本或种猪生产力水平的影响最小。本文开发和描述的模型为帮助兽医努力控制PRRSV提供了有价值的工具。
Porcine reproductive and respiratory syndrome virus (PRRSv) is a swine-specific pathogen that causes significant increases in production costs. When a breeding herd becomes infected, in an attempt to hasten control and elimination of PRRSv, some veterinarians have adopted a strategy called load-close-expose which consists of interrupting replacement pig introductions into the herd for several weeks (herd closure) and exposing the whole herd to a replicating PRRSv to boost herd immunity. Either modified-live virus (MLV) vaccine or live field-virus inoculation (FVI) is used. This study consisted of partial budget analyses to compare MLV to FVI as the exposure method of load-close-expose program to control and eliminate PRRSv from infected breeding herds, and secondly to estimate benefit/cost of vaccinating sow herds preventatively. Under the assumptions used in this study, MLV held economic advantage over FVI. However, sensitivity analysis revealed that decreasing margin over variable costs below $47.32, or increasing PRRSv-attributed cost above $18.89 or achieving time-to-stability before 25 weeks resulted in advantage of FVI over MLV. Preventive vaccination of sow herds was beneficial when the frequency of PRRSv infection was at least every 2.1 years. The economics of preventative vaccination was minimally affected by cost attributed to field-type PRRSv infection on growing pigs or by the breeding herd productivity level. The models developed and described in this paper provide valuable tools to assist veterinarians in their efforts to control PRRSv.